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Synthesis of a 5- 2-Quinolyl pyrimidine

Elucidate the following sequence of reactions and give a reasonable mechanism for the formation of intermediate C  [Pg.110]

Condensation of m-chloroaniline with ethyl acetoacetate in the presence of a catalytic amount of HC1 to give A. [Pg.110]

Heating of A in refluxing diphenyl ether to give B, CioHsClNO. [Pg.110]

Treatment of B with POCI3/DMF at 100°C followed by quench with ice and dilute NaOH to give C, C14H12Q2N2O. [Pg.110]

Reaction of C with guanidine in ethanol at reflux to give D, C13H8CI2N4. [Pg.110]


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