Pyridoxamine diabetes mellitus

Vitamin B6 (pyridoxine) and its derivative pyridoxamine are apparently able to inhibit superoxide production, reduce lipid peroxidation and glycosylation in high glucose-exposed erythrocytes [353], It was suggested that the suppression of oxidative stress in erythrocytes may be a new mechanism by which these natural compounds inhibit the development of complication in diabetes mellitus. 

Both pyridoxamine and benfotiamine have been shown to be effective in preventing or treating the vascular dysfunction syndrome associated with both experimental and clinical diabetes mellitus. This is accomplished through their participation in multiple metabolic pathways. Although in many instances pyridoxamine and benfotiamine affect the same steps in different metabolic pathways, each one has, in addition, specific sites of activity. Whether this wonld lead to synergistic effects of these compounds is yet to be investigated. 

A number of studies have suggested that vitamin Bg (and specifically pyridoxamine) may be effective in preventing the adverse effects of poor glycemic control that lead to the development of the complications of diabetes mellitus, many of which are mediated by nonenzymic glycation of proteins. Pyridoxamine is a potent inhibitor of the rearrangement of the immediate product of protein glycation to the advanced glycation end-product. ... 

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See also in sourсe #XX -- [ ]

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