Sex Differences in Metabolic Pathways

The six members of the cytochrome P450 enzyme superfamily that are primarily responsible for Phase I 

Hagg et al. (48) evaluated 611 adults, they were not genotyped and thus a gene-dose effect cannot be ruled out. Although available data are conflicting, there is not clear support of sex difference in CYP2D6 activity. 

There is little information available about sex differences in the activity of CYP2E1 and even less 

there does not appear to be a clear sex difference in the activity of the Phase I P450 isoenzymes discussed here. Most of the studies show wide inter subject variability in enzyme activity that is independent of sex. Furthermore, once data are controlled for age, weight, smoking status, and hormone use, there is little evidence for sex-dependent variability. In the future, large studies with genotype information and appropriate probe drugs will shed more light on this area. 

Drug Metabolism Interactions of Particular Importance to Women 

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