Glycation, nonenzymic

The Maillard reaction describes the nonenzymic glycation of proteins (Fig. 6). 

A number of studies have suggested that vitamin Bg may he effective in preventing the adverse effects of poor glycemic control that lead to the development of the complications of diabetes mellitus (Jain and Lim, 2001). Many of these effects are mediated hy nonenzymic glycation of proteins. Target proteins include the following ... 

Yatscoff RW, Tevaarwerk G), MacDonald JC. Quantification of nonenzymically glycated albumin and total serum protein by affinity chromatography. Clin Chem 1984 30 446-9. 

D27. Diicrocq, R., Bachour, H., Belkhodja, R., Berriche, S., and Elion, J., Evidence for nonenzymic glycation of antithrombin III in diabetic patients. Clin. Chem. 31, 338 (1985). 

E. J. Menzel and R. Reihsner, Alterations of biochemical and biomechanical properties of rat tail tendons caused by nonenzymic glycation and their inhibition by dibasic amino acids arginine and lysine, Diabetologia, 34 (1991) 12-16. 

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