Pyrene hydroxy-amino

Eine Photoaddition findet zwischen Benzo- [a]-pyren und z. B. 4-Aniino-2-hydroxy-pyrimidin (Cytosin) statt, wenn man in 4%iger, waBriger Natrium-dodecyl-sulfat-Losung belichtet. Bessere Ausbeute erhalt man mit 0,2m Xatronlauge 4-Amino-6-... 

The dependence of fluorescence spectra and intensity of fluorescence of ionizable compounds on the pH of the solution enables them to he used as fluorescence indicators. The naphthyl sulphonic acids are typical examples. In the case of hydroxy and amino pyrene sulphonic acids, sharp changes in fluorescence do not occur at the same pH values as changes in absorption. This has been explained by Forster30 by considering the attainment of the ionic equilibrium appropriate to the excited state within its life time. The fluorescence of some purines and pyrimidines also depends on the acidity or alkalinity of the medium31. 

The metabolism of nitro derivatives of PAHs is different from metabolism of the parent PAHs. Orally administrated compounds are mainly reduced to amino derivatives by intestinal microflora. Their elimination from the body occurs after oxidation to hydroxy derivatives and acetylation of amino group in the hver. Hydroxyni-tro derivatives of PAHs are the major products that are resorbed unchanged from the gastrointestinal tract. Estimation of risks from dietary intake of nitro-PAH derivatives has not been worked out in detail, with respect to the limited data on their occurrence in foods. Generally, these direct carcinogens require metabohc activation. Particularly intense mutagenic effects have been demonstrated in nitro derivatives of pyrene. 

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