Pyrazolin-4-ones

Pyrazolin-5-one, 3-methyl- H NMR, 5, 187 (B-73NMR165) 2-Pyrazolin-5-one, 3-methyl-1 -phenyl- H NMR, 5, 187 (B-73NMR165)... 

Pyran, tetrahydro-, 3 chloro 2 methyl [2H Pyran, tetrahydro, 3 chloro-2-mcthyl ], cis, trans mixture, 55, 64 2-PYRAZOLIN-5-ONES, 3-alkyl-, 55, 73 2-Pyrazolin 5-one, 3-(l-propyl)-, 55, 73 Pyridine, 2-amino-, p-bromination of, 55, 23... 

Pyrazolin-5-one, 3-alkyl-(l,2,4-thiadiazol-5-yl)-reactions, 6, 483 2-Pyrazolin-5-one, 3-amino-tautomerism, 5, 215 2-Pyrazolin-5-one, 4,4-diazido-rearrangement, 5, 720 2-Pyrazolin-5-one, 3-hydroxy-tautomerism, 5, 215 2-Pyrazolin-5-one, 3-methyl-l -phenyl-reactions, 5, 252... 

Methyl-1-phenyl-2-pyrazolin-5-one 3-Methyl-1-phenyl-5-pyrazolone. See 1-Phenyl-3-methyl-5-pyrazolone... 

Phenyl-2-methyl-2-propanol. See Dimethyl benzyl carbinol 3-Phenyl-2-methyl-propen-2-ol-1. See Methylcinnamyl alcohol 1 -Phenyl-3-methyl-5-pyrazolone CAS 89-25-8 EINECS/ELINCS 201-891-0 Synonyms Cl developer 1 Developer Z 2.4-Dihydro-5-methyl-2-phenyl-3H-pyrazol-3-one 3-Methyl-1 -phenyl-2-pyrazolin-5-one 3-Methyl-1 -phenyl-5-pyrazolone Norantipyrine Norphenazone 1-Phenyl-3-methyl-5-oxo-2-pyrazoline 1-Phenyl-3-methylpyrazolone-5 5-Pyrazolin-5-one, 3-methyl-1-phenyl-5-Pyrazolone, 3-methyl-1-phenyl-Empirical C10H10N2O Formula C6HsNN C(CH3)CH2CO Properties Wh. to It. yel. powd. orcryst. sol. 10-50 mg/ml in DMSO, 95% ethanol, acetone si. sol. in benzene sol. < 1 mg/ml in water insol. in ether, petrol, ether m.w. 174.20 vapor pressure < 0.01 mm Hg (20 C) m.p. 127-130 C b.p. 287 C (105 mm) ref. index 1.637 (20 C)... 

Methyl-l-phenyl-2-pyrazolin-5-one (MCI-186) is a potent scavenger of hydroxyl radicals inhibiting not only hydroxyl radicals but iron-induced per-oxidative injury (Watanabe etal. 1988, Muroto et al. 1990). After the reaction with peroxy radicals, MCI-186 changes into 2-oxo-3-(phenylhydrazone)-butanoic acid (Yamamoto et al. 1996, Kawai et al. 1997). In a thrombotic rat distal middle cerebral artery occlusion model, 3-methyl-l-phenyl-2-pyrazolin-5-one (3 mg/kg) significantly P < 0.05) decreased the size of the cerebral infarct 1 day after artery occlusion (Kawai et al. 1997). 

A mixture of isatin (1 2 mmol), malononitrile (2 145 mg, 2.2 mmol), 2-pyrazolin-5-one (3 2.2 mmol), and sodium bicarbonate (504 mg, 6 mmol) was ground at room temperature with a glass mortar and pestle the reaction was found to become completed within 7 min (monitored by TLC). Upon completion of the reaction, the precipitate is collected by suction filtration and washed with water. The crude product was recrystallized from ethanol and dried under room temperature to obtain pure spiropyranyl-oxindole 4. All the products were characterized by spectral studies. 

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