Purinergic systems nervous system

Gibb, AJ and Halliday, EC (1996) Fast purinergic transmission in the central nervous system. In Seminars in the Neurosciences (Ed. Burnstock, G), pp. 225-232. 

A1 adenosine receptors are inhibitory in the central nervous system. A receptors were originally characterized on the basis of their ability to inhibit adenylyl cyclase in adipose tissue. A number of other G-protein-mediated effectors of A receptors have subsequently been discovered these include activation of K+ channels, extensively characterized in striatal neurons [13], and inhibition of Ca2+ channels, extensively characterized in dorsal root ganglion cells [14]. Activation of A receptors has been shown to produce a species-dependent stimulation or inhibition of the phosphatidylinositol pathway in cerebral cortex. In other tissues, activation of A receptors results in synergistic activation of the phosphatidylinositol pathway in concert with Ca2+-mobilizing hormones or neurotransmitters [15]. The effectors of A adenosine receptors and other purinergic receptor subtypes are summarized in Table 17-2. 

Burnstock G, Verkhratsky A. Early history of purinergic signalling. In Puriner-gic Signalling and the Nervous System. Berlin/Heidelberg Springer 2012, Vol. 18, pp. 1-66. 

Abbracchio MP, Burnstock G, Verkhratsky A, Zimmermann H. Purinergic signalling in the nervous system an overview. Trends Neurosci 2009 32 19-29. 

Burnstock G. Purinergic signalling and disorders of the central nervous system. Nature reviews. Drug Discov 2008 7 575—90. 

North RA, Verkhratsky A. Purinergic transmission in the central nervous system. Pflugers Arch. 2006 452(5) 479-485. 

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