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Purinergic

Purinergic System Adenosine Receptors Sterol Transporters... [Pg.19]

Enzyme inhibitors (e.g. metalloproteinases, cathepsin K) Purinergic modulators... [Pg.280]

Vascular Endothelial Growth Factor Nitric Oxide Purinergic System... [Pg.470]

The receptors GPR4, OGR1, and TDAG8 form a subfamily of GPCRs distantly related to purinergic and... [Pg.1035]

The first clear evidence for nerve-nerve purinergic synaptic transmission was in 1992, when it was... [Pg.1050]

Purinergic System. Figure 2 Schematic of sympathetic cotransmission. ATP and NA released from small granular vesicles (SGV) act on P2X and a-i receptors on smooth muscle, respectively. ATP acting on inotropic P2X receptors evokes excitatory junction potentials (EJPs), increase in intracellular calcium ([Ca2+]j) and fast contraction while occupation of metabotropic ar-adrenoceptors leads to production of inositol triphosphate (IP3), increase in [Ca2+]j and slow contraction. Neuropeptide Y (NPY) stored in large granular vesicles (LGV) acts after release both as a prejunctional inhibitory modulator of release of ATP and NA and as a postjunctional modulatory potentiator of the actions of ATP and NA. Soluble nucleotidases are released from nerve varicosities, and are also present as ectonucleotidases. (Reproduced from Burnstock G (2007) Neurotransmission, neuromodulation cotransmission. In Squire LR (ed) New encyclopaedia of neuroscience. Elsevier, The Netherlands (In Press), with permission from Elsevier). [Pg.1051]

Purinergic signalling is also concerned with longterm events, such as cell proliferation, migration, differentiation and death associated with development and regeneration [1, 3, 4]. For example, a,(3-methylene ATP produces proliferation of glial cells, whereas adenosine inhibits proliferation. A p2y8 receptor was... [Pg.1051]

There is increasing interest in the therapeutic potential of purinergic compounds in relation to both PI and P2 receptors [4]. A number of purine-related compounds have been patented. [Pg.1051]

Abbracchio MP, Williams M (eds) (2001) Purinergic and Pyrimidinergic Signalling. Handbook of experimental pharmacology, vol 151 (I/II). Springer, Berlin... [Pg.1053]

Burnstock, G (2006) Pathophysiology and therapeutic potential of purinergic signalling. Pharmacol Rev 58 58-86... [Pg.1053]

Burnstock, G (2007) Physiology and pathophysiology of purinergic neurotransmission. Physiol Rev 87 659-797... [Pg.1053]

A purinoceptor is a cell surface receptor for the purinergic nucleotides ATP and ADP and for the purine nucleotide, adenosine. [Pg.1053]

Schneider G, Nettekoven M. Ligand-based combinatorial design of selective purinergic receptor (A2A) antagonists using self-organizing maps. J Comb Chem 2003 5 233-7. [Pg.372]

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See also in sourсe #XX -- [ Pg.2 , Pg.12 , Pg.109 , Pg.113 , Pg.129 ]

See also in sourсe #XX -- [ Pg.456 ]



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Purinergic Neuromodulation and the Adenosine Receptors

Purinergic mechanisms

Purinergic signaling

Purinergic systems

Purinergic systems adenosine

Purinergic systems adenosine receptors

Purinergic systems nervous system

Purinergic systems receptors

Receptors purinergic

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