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Pulsatile drug-release patterns

Figure 11 Pulsatile drug-release patterns negligible release at early time points, followed by rapid and complete release after a predetermined lag phase. Exemplarily, a polymer-coated pellet is Ulustrated The intact macromolecular membrane effectively hinders drug release until the steadily increasing hydrostatic pressure within the pellet core (caused by the influx of water) induces crack formation, resulting in rapid drug release through water-filled pores/chaimels. Figure 11 Pulsatile drug-release patterns negligible release at early time points, followed by rapid and complete release after a predetermined lag phase. Exemplarily, a polymer-coated pellet is Ulustrated The intact macromolecular membrane effectively hinders drug release until the steadily increasing hydrostatic pressure within the pellet core (caused by the influx of water) induces crack formation, resulting in rapid drug release through water-filled pores/chaimels.
New routes of administration transmucosal specific regional uptake in gastrointestinal tract New pattern of drug release bolus/flrst order/pulsatile feedback control disease-related release of drug... [Pg.548]

Several delivery systems with sigmoidal or pulsatile release patterns were derived on this ion exchange. The sigmoidal release system (SRS) consisted of pellet cores, containing drug and succinic acid, coated with Eudragit The lag time was controlled by the... [Pg.1290]

ERPs poly(2-acrylamido-2-metliyl-propane sulphonic acid-co-n-butylmethacrylate) based were used to delivery edrophonium hydrochloride and hydro-cortisone in a pulsatile manner [83]. The control of drug release was achieved by varying the intensity of electric stimulation in distilled deionized water. For a positively charged drug, the release pattern depends on ion exchange between hydrogen ion produced by electrolysis of water and positively charged solute. [Pg.351]

Designed to deliver insoluble drugs that require high loading, with an optional delayed, patterned, or pulsatile release profile. [Pg.1250]

See other pages where Pulsatile drug-release patterns is mentioned: [Pg.19]    [Pg.19]    [Pg.11]    [Pg.574]    [Pg.157]    [Pg.409]    [Pg.410]    [Pg.383]    [Pg.141]    [Pg.254]    [Pg.36]    [Pg.663]    [Pg.388]    [Pg.530]    [Pg.141]    [Pg.1012]    [Pg.105]    [Pg.107]   
See also in sourсe #XX -- [ Pg.19 ]



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