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Sigmoidal release system

Several delivery systems with sigmoidal or pulsatile release patterns were derived on this ion exchange. The sigmoidal release system (SRS) consisted of pellet cores, containing drug and succinic acid, coated with Eudragit The lag time was controlled by the... [Pg.1290]

Narisawa, S. Nagata, M. Danyoshi, C. Yoshino, H. Murata, K. Hirakawa, Y. Noda, K. An organic acid-induced sigmoidal release system for oral controlled-release preparations. Pharm. Res. 1994, 11 (1), 111-116. [Pg.1296]

In this equation, m is the slope of the relationship, and C is the intercept. Ideally, m = 1 and C = 0, indicating a linear relationship. However, depending on the nature of the modified-release system, some data are better fitted using nonlinear models, such as Sigmoid, Weibull, Higuchi, or Hixson-Crowell. [Pg.154]

Among various initial concentration distributions in a matrix, the sigmoidal drug distribution or a staircase distribution resembling a sigmoidal pattern furnishes zero-order release kinetics for the planar geometry. There are various methods to build concentration gradient matrix systems. The most convenient way to achieve the... [Pg.407]

See other pages where Sigmoidal release system is mentioned: [Pg.166]    [Pg.166]    [Pg.206]    [Pg.1287]    [Pg.206]    [Pg.300]    [Pg.304]    [Pg.312]    [Pg.322]    [Pg.100]    [Pg.279]    [Pg.280]    [Pg.78]    [Pg.14]    [Pg.71]    [Pg.1857]    [Pg.177]    [Pg.481]    [Pg.333]    [Pg.439]   
See also in sourсe #XX -- [ Pg.1290 ]



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