Pulmonary metabolism

Systemic complications may include cardiovascular, renal, pulmonary, metabolic, hemorrhagic, and CNS abnormalities. 

Leong, B.K.J., Coombs, J.K., Petzold, E.N. and Hanchar, A.J. (1988). A dosimetric endotracheal nebulization technique for pulmonary metabolic disposition studies in laboratory animals. Inhal. Toxicol, (premier issue) 37-51. 

Gillespie MN, Krechniak JW, Crooks PA, Altiere RJ, Olson IW (1985) Pulmonary metabolism of exogenous enkephalins in isolated perfused rat lungs. J Pharmacol Exp Ther 232 675-681. 

Keywords Bronchial epithelium Pulmonary drug absorption Pulmonary metabolism Drug transport Permeability... 

Keywords Pneumocytes Pulmonary drug delivery Pulmonary metabolism, Alveolar epithelium... 

Paddle, GM., Osborn, A.J. Parker GD.J. (1991) Mortality of employees in plants manufacturing 4,4 -bipyridyl. Scand. J. Work. Environ. Health, 17, 175-178 Page, D.A. Carlson, GP. (1993) Effect of pyridine on the hepatic and pulmonary metabolism of 2-bntanol in rat and rabbit. J. Toxicol, environ. Health, 38, 369-379 Pellizzari, E.D., Castillo, N.P. Willis, S. (1979) Identification of organic components in aqneons efflnents from energy-related processes. In Van Hall, ed., Measurements of Organic Pollutants in Water and Wastewater (ASTM STP, 686), Philadelphia, PA, American Society for Testing and Materials, pp. 256-274... 

Cohen GM. Pulmonary metabolism of foreign compounds Its role in metabolic activation. Environ. Health Per spec t 85 31 1990. 

De Flora S, Petruzelli S, Camoirano A, et al. 1987b. Pulmonary metabolism of mutagens and its relationship with lung cancer and smoking habits. Cancer Res 47 4740-4745. 

Local complications in severe AP may include acute fluid collection, pancreatic necrosis, abscess, pseudocyst formation, and pancreatic ascites. Systemic complications may include cardiovascular, renal, pulmonary, metabolic, hemorrhagic, and CNS abnormalities. 

Systemic availability of inhaled drugs may be inhibited by first-pass pulmonary metabolism. The lungs contain many drug metabolizing enzymes, including mixed function oxidases, monoamine oxidase, and esterases. 

A final, and not insignificant, consideration is the problem of drug metabolism in the respiratory tract. Although a large body of data indicates that pulmonary metabolism is generally relatively lower than hepatic metabolism [28], it is clear that nearly all of the drug metabolism activities found in the liver are present in the respiratory tract [1,25]. In addition, some respiratory tissues... 

Kacew S, Parulekar MR, Merali Z. 1982. Effects of parenteral vanadium administration on pulmonary metabolism of rats. Toxicol Lett 11 119-124. 

Foth H, Rudell U, Ritter G, et al. 1988b. Inhibitory effect of nicotine on benzo(a)pyrene elimination and marked pulmonary metabolism of nicotine in isolated perfused rat lung. Klin Wochenschr 66(Suppl 11 ) 98-104. 

Acute, and sometimes fatal, complications of pulmonary, metabolic, renal, and hepatic functions result from formaldehyde intoxication (Feinman 1988b Gosselin et al. 1984). No strong evidence links formaldehyde to significant and consistent neurotoxicity (Bar-dana and Montanaro 1987). 

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