Pulmonary eosinophilia, drug-induced

Nonsteroidal anti-inflammatory medications may occasionally induce pulmonary infiltrates and eosinophilia. Drug-induced lupus erythematosus and non-cardiogenic pulmonary edema have also been described. 

Assessment of Pulmonary Targeting in Animal Models. Animal models are important tools in assessing the pharmacodynamic performance of antiasthma drugs. Pulmonary models have been developed for rat and mice, which allow the assessment of anti-inflammatory properties of a drug after antigen challenge. Alternatively, pulmonary eosinophilia can be induced by nonallergic modes,... 

Farer LS (1976) Isoniazid and liver injury. Ann Intern Med 84 753 Feinmann L (1975) Lung parenchymal changes due to ingested substances. Drug-induced lung disease pulmonary eosinophilia and sulphonamides. Proc R Soc Med 68 440 Fellner MJ (1970) Nebenwirkungen durch Isonicotinsaurehydrazid. Hautarzt 21 320 Flach A (1981) Photosensitivity to sulfisoxazole ointment. Arch Ophthalmol 99 609 Fleck R (1981) Nitrofurantoin toxicity. Pa Med 84 36... 

Vaccines and desensitization have been suspected to trigger or act as adjuvant factors in the development of CSS (110,111), and are thus considered contraindicated in patients with overt CSS. The possible responsibility of leukotriene-receptor antagonists (montelukast, zafirlukast, pranlukast) in the development of CSS has been debated (90,112), with no established causative role in epidemiological studies. However, some rather convincing case reports or personal observations lead us to consider that these agents should be avoided in asthmatic patients with eosinophilia and (or) extrapulmonary manifestations. Drug-induced eosinophilic vasculitis with pulmonary involvement has been occasionally reported. CSS has developed in an asthmatic patient a few months after starting omalizumab, an anti-IgE antibody (113). 

Drugs That Induce Pulmonary Infiltrates with Eosinophilia (Loeffler s Syndrome)... 

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