Pteroylmonoglutamic acid

The major sources of folate are green vegetables, citrus fruits, legumes, egg yolk, wheat germ, and yeast [417]. This vitamin can be added only in the form of pteroylmonoglutamic acid [402]. The multiplicity of forms, low stability, low concentration, and the complex extraction and detection techniques make the analysis of folate in food a difficult task. 

SYNS l-N-(p-(((-2-AMINO-4-HYDROXY-6-PTERIDIN-YL)METHYL)AMINO)BENZOYL)GLUTAAaC ACID FOLACIN FOLATE FOLCYSTEINE NSC-3073 PTEGLU PTEROYLGLUTAMIC ACID PTEROYL-l-GLUTANOC ACID PTEROYLMONOGLUTAMIC ACID... 

Synonyms Folacin Folate Pteroylmonoglutamic acid 4-(2-Amino-4-hydroxypteridin-6-yl)methyl-aminobenzoyl-L-glutamic acid... 

The chemical name for folic acid is pteroylmonoglutamic acid. It is made up of three moieties p-aminobenzoic acid, glutamic acid and a pteridine nucleus. 

The tetrahydrofolate derivative (Formula (6.16), II) of folic acid (I, pteroylmonoglutamic acid, PGA) is the cofactor of enzymes which trans-... 

There is no single compound vitamin with the name folacin rather, the term folacin is used to designate folic acid (pteroylmonoglutamic acid, or PGA) and a group of closely... 

Through the years, several names other than folacin and folic acid have been given to this vitamin, including Wills factor, pteroylmonoglutamic acid, antianemia factor PGA, vitamin M, vitamin Be, SLR factor, factor R, factor U, vitamin U, Lactobacillus casei factor citrovoram factor (CF) yeast Noriteluatefactor, vitamin B-vitamin B-10, and vitamin B-11. 

There may be a case for using folate with a long-chain glutamic acid residue such as that contained in yeast for absorption studies rather than a pteroylmonoglutamate. This should provide more useful information on the patient s ability to absorb food folates. However, in practice this is seldom done. 

In the structure of the vitamin folic acid, 6-methylpterin is linked through the amino group of p-aminobenzoic acid (PABA) to form pteroic acid, which is linked in turn via an amide to glutamate, to form pteroylmonoglutamate. 

---