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Pseudomonas aeruginosa, toxin produced

The best understood reactions are those catalyzed by ADP-ribosyl transferase components of certain bacterial toxins. These include, for example, toxins produced by Vibrio cholerae (the causative agent of cholera), pertussis toxin (from Bordetella pertussis, which causes whooping cough), diphtheria toxin, exotoxin A from Pseudomonas aeruginosa (an opportunistic pathogen), and toxins from Clostridium botulinum. [Pg.314]

Exotoxin A produced by the aerobic bacterium Pseudomonas aeruginosa (128) possesses the same catalytic activity as diphtheria toxin (120, 129), including ADP-ribosylation of EF-2 on the same site (115). The reaction is reversible because ADP-ribosylated EF-2 produced by exotoxin A can be deribosylated (functional activity restored) by incubating with excess nicotinamide and either excess exotoxin A or subunit A of diphtheria toxin. NAD+ was identified as the sole product of this reverse reaction (115). These results also establish that the configuration and site of ADP-ribosylation catalyzed by exotoxin A are identical to those of diphtheria toxin. [Pg.491]

See other pages where Pseudomonas aeruginosa, toxin produced is mentioned: [Pg.651]    [Pg.246]    [Pg.200]    [Pg.150]    [Pg.752]    [Pg.188]    [Pg.261]    [Pg.683]    [Pg.56]    [Pg.422]    [Pg.56]    [Pg.422]    [Pg.471]   
See also in sourсe #XX -- [ Pg.752 ]



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