Pseudoephedrine hypertension caused

SYMPATHOMIMETICS CYTOTOXICS -PROCARBAZINE Co-administration of ephedrine, metaraminol, methylphenidate, phenylephrine or pseudoephedrine (including nasal and ophthalmic solutions) with procarbazine may cause a prolongation and t intensity of the cardiac stimulant effects and effects on BP, which may lead to headache, arrhythmias, hypertensive or hyperpyretic crisis The metabolism of sympathomimetics is impaired due to an inhibition of MAO It is recommended that sympathomimetics not be administered during and within 14 days of stopping procarbazine. Do not use any OTC nasal decongestants (sprays or oral preparations) or asthma relief agents without consulting the pharmacist/doctor... 

Pseudoephedrine is a component of some non-prescription basal decongestants given by mouth even quite ordinary doses of such products (for example 120 mg) can cause a hypertensive reaction in sensitive subjects, such as those with a pheochromocytoma and those with at least a family history of hypertension (SEDA-17,162). 

Sympathomimetics (indirectly acting) Combining MAOis with agents such as amphetamines, cocaine, ephedrine, methylphenidate, pemoline, pseudoephedrine, phenylpropanolamine, and others (including many cold and allergy medications) can cause a potentially fatal hypertensive crisis. 

Not understood. Severe hypertension occasionally occurs with either bromocriptine or phenylpropanolamine given alone. Shortly after giving birth some individuals show increased vascular reactivity, and it could be that all of these factors conspired together to cause these adverse effects. Psychosis occasionally occurs after giving birth or on bromocriptine alone, so that in the latter case the addition of pseudoephedrine may have been coincidental. ... 

Ephedrine, pseudoephedrine, and norpseudoephedrine are now produced primarily by synthesis. Ephedrine is used as a bronchodilator for treating the symptoms of asthma and for treating coughs. Pseudoephedrine and norpseudoephedrine are used for the same purposes and are included in formulae for over-the-counter remedies for treating symptoms of the common cold. All three of these alkaloids cause a rise in blood pressure and this is a deterrent to their use in patients with hypertension. 

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