Pseudoarachniotus roseus

Mukhopadhyay T, Bhat RG, Roy K, Vijayakumar EKS, Ganguli BN (1998) Aranochlor A and Aranochlor B, Two New Metabolites from Pseudoarachniotus roseus Production, Isolation, Structure Elucidation and Biological Activities. J Antibiot 51 439... 

Total synthesis of a novel antibiotic, aranorosin (23), which was isolated from the fermentation broth of Pseudoarachniotus roseus, was accomplished by Rama Rao et al. [98], Wipf et al. [99], and McKillop et al. [100] via the construction of spirolactone (141) using PIFA or PIDA (Scheme 14). 

The antibiotic aranorosin (39) has a unique structural feature. The molecule contains a tetracyclic nucleus derived from a cyclohexanone bis-epoxide l-oxaspiro[4.5]decane ring system which is linked to a dienamide derived from a fatty acid containing a stereocenter at the 6 position. Aranorosin was isolated from the fungal strain Pseudoarachniotus roseus [68] and was shown to posses not only antibiotic but also antifungal and antineoplasic activity [68,69],... 

Two new compounds named aranochlors A (188) and B (189) were detected as minor components from the fermented broth of the fungal strain Pseudoarachniotus roseus [216]. Fermentations were carried out in shake flasks as well as in laboratory fermenters. For the isolation of 188 and 189 six batches of each 100 liters were processed. Both compounds were present both in the culture filtrate and the mycelium. Both aranochlors exhibited antibacterial and antifungal activities. The... 

---