Proteoglycans linkage region

Scheme 21. Synthesis of oligosaccharide 118 of the proteoglycan linkage-region via active-...

J. G. Allen and B. Fraser-Reid, n-Pentenyl glycosyl orthoesters as versatile intermediates in oligosaccharide synthesis. The proteoglycan linkage region,./. Am. Chem. Soc., 121 (1999) 468-469. 

Fig. 2.—Schematic Representation of the Heparin Proteoglycan. [The polysaccharide chains, bound to the polypeptide matrix through a linkage region," are cleaved by tissue endoglycosidases (arrows) after the transformations illustrated in Scheme 1.]...

These conformations were subjected to a combined MD/EM refinement using the NOESY derived constraints as pseudoenergy functions. Families of conformations for the whole molecule were then constructed from the structures derived for each linkage. This procedure was demonstrated on a fragment from the carbohydrate-protein linkage region of connective tissue proteoglycans. 

We will illustrate our methodology using 0-3-D-galactopyranosyl -(1->4) 0-3 D-xylopyranosyl-(1->0)-L-serine (GXS), a fragment from the carbohydrate-protein linkage region of xylose/serine linked proteoglycans. 

Synthesis of an O-Linked Glycopeptidomimetic (Glycopeptoid) Corresponding to the Linkage Region of Proteoglycans... 

MOLECULAR STRUCTURE OF THE CARBOHYDRATE-PROTEIN LINKAGE REGION FRAGMENTS FROM CONNECTIVE-TISSUE PROTEOGLYCANS... 

Oligosaccharide Fragments Isolated from the Carbohydrate-Protein Linkage-Region of Dermatan Sulfate Proteoglycans 1... 

Sugahara K, Yamashina 1, Dewaard P, Vanhalbeek H, Vhegen-thart JFG. Structural studies on sulfated glycopeptides from the carbohydrate-protein linkage region of chondroitin 4-sulfate proteoglycans of swarm rat chondrosarcoma - demonstration of 86. the structure Gal(4-0-Sulfate)-P-l-3-Gal-P-l-4Xyl-P-l-0-Ser. J. 

Rio, S, Beau, J-M, Jacquinet, J-C, Synthesis of glycopeptides from the carbohydrate-protein linkage region of proteoglycans, Carbohydr. Res., 219, 71-90, 1991. 

Structure of the linkage region GlcA(j31-3)Gal(j31-3)Gal(j31-4)Xyl(j31-0)Serof proteoglycans... 

R421 N. R. Krishna and P. K. Agrawal, Molecular Structure of the Carbohydrate-Protein Linkage Region Fragments from Connective-Tissue Proteoglycans , Adv. Carbohydr. Chem. Biochem., 2001, 56, 201... 

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