Proteoglycan blood vessel

The rest of the liver volume (about 15%) consists of intravascular space, the space of Disse, lymphatic vessels, and extracellular matrix molecules [8], These matrix proteins, located predominantly in the space of Disse and around blood vessels, consist mainly of basement membrane molecules (collagen type IV, laminin, and fibronectin) and fibronectin) and small amounts of collagen type I, III, VI, undulin, tenascin, and proteoglycans. The matrix proteins determine the specific phenotype and functions of many resident hepatic cells [9-11],... 

An important factor in the distribution of drugs is the permeability of the capillaries. Capillaries are the microscopically small blood vessels across the very thin walls of which metabolites and gases are exchanged between blood and tissues. Capillaries have a cellular layer - the endothelium, supported by a basal membrane consisting of proteins and proteoglycans (Figure microcirculation). 

The stroma within which the principal periodontal fibers are embedded is composed of proteoglycans within which are embedded oxytalan fibers (Sect. 3.1.3) whose elasticity is important (Sect. 3.1.3). Mini-oxytalan fibers surround blood vessels and are attached to... 

Once in the blood vessels, the sporozoites do not adhere to proteoglycans on the vascular endothelial surface until they enter a sinusoid of the liver. To infect the liver hepatocytes the parasites must cross a sinusoidal barrier composed of special endothelial cells and Kupffer cells (the resident macrophages). Kupffer cells, by virtue of their highly exposed fixed position in the sinusoidal lumen and the presence of sporozoite receptors, provide access to the space of Disse and act as a portal of entry for the sporozoite into the liver hepatocyte (Frevert et al., 2006). It is clear from a study where two different Kupffer cell-deficient murine models were compared, that is mice with a genetic defect in CSPF-1 expression and... 

The skin is an excellent barrier to microbial and parasitic infections. The most superficial layer of the skin is composed of flattened squamous cells, which are highly keratinized. Beneath this is the epidermal layer composed of cells tightly interconnected by desmosomes and other intercellular structures. These, in turn, are attached to the basement membrane composed of covalently bound or interwoven macromolecules. Between the basement membrane and a target blood vessel is an extracellular matrix rich in type I collagen, elastin and proteoglycan. Elastin and type I collagen are both interwoven fibrillar molecules, whereas the carbohydrate-rich proteoglycan behaves like a hydrated gel. For details of these macromolecular interactions, the reader is referred to reviews on the structure of skin. 

The neurovascular unit places stroke in the context of an integrative tissue response in which all cellular and matrix elements, not just neurons or blood vessels, are players in the evolution of tissue injury. For example, efficacy of the blood-brain barrier is critically dependent upon endothelial-astrocyte-matrix interactions [93]. Disruption of the neurovascular matrix, which includes basement membrane components such as type IV collagen, heparan sulfate proteoglycan, laminin, and... 

The generally held view, for which considerable evidence exists, suggests that lipoprotein lipase exerts its functional activity against chylomicron and VLDL triacylglycerol, following activation by apoprotein-Cji, while both enzyme and substrate are sequestered at the endothelial cell surface of extrahepatic tissue blood vessels. The enzyme and possibly also the substrate are bound to the lumenal surface of the endothelial cells by specific non-covalent interactions with the glycosaminoglycans and proteoglycans present (Cryer, 1981). 

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