Protein purification technolog precipitation methods

Shortcomings in current understanding of the thermodynamics of protein solutions can be illustrated by considering one of the oldest protein concentration methods, precipitation, and one of the newest and most technologically interesting methods for protein separation and purification, aqueous... 

Purification can also be achieved in other ways, through precipitation with salts, crystallization, and through aqueous two-phase extraction. Some of these methods are associated with substantial capital cost, low throughput, low yields, or waste issues. Fractional precipitation, one of the oldest protein separation technologies, can be surprisingly effective to separate a compound of interest from a complex broth. For instance, the process of fractional solvent precipitation of blood plasma components has been used since World War II. 

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