Protein-associated factor

Jin, Y., et al., MDM2 mediates p300/ CREB-binding protein-associated factor ubiquitination and degradation. 

Pan, C., Mezei, M., Mujtaba, S., Muller, M., Zeng, L., Li, J., Wang, Z. and Zhou, M.M. (2007) Structure-guided optimization of small molecules inhibiting human immunodeficiency virus 1 Tat association with the human coactivator p300/CREB binding protein-associated factor. Journal of Medicinal Chemistry, 50, 2285-2288. 

Table 1.L General initiation factors of transcription by RNA polymerase II After Roeder (1996). TAF TATA box binding protein associated factor TBP TATA box binding protein RNA Pol II RNA polymerase II...

TBP TATA box binding protein, TAF TATA box binding protein associated factor, SRB suppressor of RNA polymerase B, CTD C-terminal domain of RNA polymerase II, PC positive cofactor, NC negative cofactor, HMG high mobihty group proteins, UAS upstream activating sequence. 

TATA Box Binding Protein Associated Factors (TAFs)... 

J. D. Fondell, M. Guermah, S. Malik, and R G. Roeder. Thyroid hormone receptor-associated proteins and general positive cofactors mediate thyroid hormone receptor function in the absence of the TATA box-binding protein-associated factors of TFIID. Proc Nad Acad. Sci, VSA, 96 (5), 1959-1964, 1999. 

TATA box-binding protein-associated factor 10, a component of the general transcription factor complex TFllD and the TATA box-binding protein (TBP)-free TAF-containing complex... 

Nonhistone proteins are known to be methylated on Fys residues, which include transcription factors, such as p53 (78-80), TAFIO (TATA box-binding protein-associated factor 10) (81), and translation factors (63). The p53 protein can be methylated by different methyltransferases [Set9, (78) Smyd2 (79), and Set8 (80)] on different Fys residues (Lys372, 370, and 382, respectively). These different methylation events either activate or repress p53 activity. Arg methylation has been found frequently in nonhistone proteins. For example. 

TATA-box-binding protein associated factor (TAP) chromatin-remodeling engine histone deacetylase... 

Martinez E., Chiang C.-M., Ge H., Roeder R. G. (1994) TATA-binding protein-associated factor(s) in TFIID function through the initiator to direct basal transcription from a TATA-less class II promoter. EMBO J 13 3115. 

Abbreviations used CTD, carbota -tenninal doinain of pol II RNA pol II, RNA polymerase II TAFs, TATA-bindiiig protein-associated factors TEP, TATA-binding protein,... 

Fig. 3. TATA-binding protein/TATA-binding protein-associated factor complexes.

Maskin is a cytoplasmic polyadenylation element-binding protein-associated factor. Dormant state of maternal mRNAs in immature oocytes is maintained by an abortive interaction of this protein with the eukaryotic initiation factors 4E and 4G. Phosphorylation of maskin promotes the dissociation of this interaction, thereby allows the dormant mRNAs to be translated actively. Aurora phosphorylation of maskin is reported to be involved in protein synthesis in maturing clam and Xenopus oocytes and in centrosome-dep>endent microtubule assembly at mitosis (Kinoshita et al. 2005 Pascreau et al. 2005). 

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