TATA box binding protein associated factor

Table 1.L General initiation factors of transcription by RNA polymerase II After Roeder (1996). TAF TATA box binding protein associated factor TBP TATA box binding protein RNA Pol II RNA polymerase II...

TBP TATA box binding protein, TAF TATA box binding protein associated factor, SRB suppressor of RNA polymerase B, CTD C-terminal domain of RNA polymerase II, PC positive cofactor, NC negative cofactor, HMG high mobihty group proteins, UAS upstream activating sequence. 

TATA Box Binding Protein Associated Factors (TAFs)... 

J. D. Fondell, M. Guermah, S. Malik, and R G. Roeder. Thyroid hormone receptor-associated proteins and general positive cofactors mediate thyroid hormone receptor function in the absence of the TATA box-binding protein-associated factors of TFIID. Proc Nad Acad. Sci, VSA, 96 (5), 1959-1964, 1999. 

TATA box-binding protein-associated factor 10, a component of the general transcription factor complex TFllD and the TATA box-binding protein (TBP)-free TAF-containing complex... 

Nonhistone proteins are known to be methylated on Fys residues, which include transcription factors, such as p53 (78-80), TAFIO (TATA box-binding protein-associated factor 10) (81), and translation factors (63). The p53 protein can be methylated by different methyltransferases [Set9, (78) Smyd2 (79), and Set8 (80)] on different Fys residues (Lys372, 370, and 382, respectively). These different methylation events either activate or repress p53 activity. Arg methylation has been found frequently in nonhistone proteins. For example. 

TATA-box-binding protein associated factor (TAP) chromatin-remodeling engine histone deacetylase... 

Figure 9.2 Schematic model for transcriptional activation. The TATA box-binding protein, which bends the DNA upon binding to the TATA box, binds to RNA polymerase and a number of associated proteins to form the preinitiation complex. This complex interacts with different specific transcription factors that bind to promoter proximal elements and enhancer elements.

The general transcription factor TFllD is believed to be the key link between specific transcription factors and the general preinitiation complex. However, the purification and molecular characterization of TFllD from higher eucaryotes have been hampered by its instability and heterogeneity. All preparations of TFllD contain the TATA box-binding protein in combination with a variety of different proteins called TBP-associated factors, TAFs. When the preinitiation complex has been assembled, strand separation of the DNA duplex occurs at the transcription start site, and RNA polymerase II is released from the promoter to initiate transcription. However, TFIID can remain bound to the core promoter and support rapid reinitiation of transcription by recruiting another molecule of RNA polymerase. 

HRE - hormone response element TAFs - TBP-associated factors TBP - TATA box-binding protein A-H - basal transcription factors... 

B. Coulombe, J. Li and J. Greenblatt. Topological localization of the human transcription factors UA, IIB, TATA box-binding protein, and RNA polymerase U-associated protein 30 on a class U promoter. J Biol Chem 269 (1994) 19962-7. 

S.K. Mahanta, T. Scholl, F.C. Yang and J.L. Strominger. Transactivation by Cll l A, the type n bare lymphocyte syndrome- associated factor, requires participation of multiple regions of the TATA box binding protein. Proc. Natl. Acad. Sci. USA 94... 

TFIIA, TFIIB, TFIID, TFIIE, TFIIF, and TFIIH are the general transcription factors. TFIID is also the TATA-box binding protein and is associated with TAFs (TBP associated factors). 

---