Protease inhibitors, interactions

C.J. Bachmeier, T.J. Spitzenberger, W.F. Elmquist, and D.W. Miller. Quantitative assessment of HIV-1 protease inhibitor interactions with drug efflux transporters in the blood-brain barrier. Pharm Res. 22 1259-1268 (2005). 

Komiyama T, et al. Optimization of protease-inhibitor interactions by randomizing adventitious contacts. Proc. Natl. Acad. Sci. 

Christeller, J.T., Laing, W.A., Markwick, N.P. and Burgess, E.P.J. (1992). Midgut protease activities in 12 phytophagous lepidopteran larvae - Dietary and protease inhibitor interactions. Insect Biochem. Mol. Biol. 22, 735-746. 

Uchman, M., Cigler, R, Grtiner, B. et al. 2010b. MiceUe-hke nanoparticles of block copolymer poly(ethylene oxide)-h/oc -poly(methacrylic acid) incorporating fluorescently substituted metallacarboranes designed as HIV protease inhibitor interaction probes. J. Colloid Interface Sci. 348 129-136. 

Pharmacokinetic interactions between cyclosporine and protease inhibitors in HIV+ subjects. Drug Metab Pharmacokinet 18 114-120... 

Clinically relevant drug interactions Nitrates, protease inhibitors, Nitrates, a,-blockers3, Nitrates, anti-arrhythmic... 

Although many patients believe that dietary supplements will not interact with medications, recent literature suggests otherwise. Recently, many St. John s wort-drug interactions have been reported in the literature. Cases of patients developing symptoms of serotonin syndrome have been reported with St. John s wort alone and in concomitant therapy with other antidepressants such as monoamine oxidase inhibitors, serotonin reuptake inhibitors, and venlafaxine. St. John s wort may exacerbate the sedative effects of benzodiazepines, alcohol, narcotics, and other sedatives. St. John s wort may decrease the levels of protease inhibitors, cyclosporine, digoxin, and theophylline. 

Compatibility with many of the additives used to prevent protein interactions, and maintain sample stability and solubility (detergents, denaturants, and reductants, and protease inhibitors). 

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