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Prostaglandins , drugs, role

Hayaishi, O. Huang, Z. L. (2004). Role of orexin and prostaglandin E2 in activating histaminergic neurotransmission. Drug News Perspec. 17, 105-9. [Pg.380]

F. Role in therapy According to Micromedex, oxytocin is routinely used for the induction of labor at term and postpartum for the control of uterine bleeding. Oxytocin is not the drug of choice for induction of labor for abortion. Oxytocin infusion has been used following prostaglandin or hypertonic abortifacients to shorten the induction to abortion time when inducing second-trimester abortion, inducing abortion when a patient has failed to respond to the abortifacient, or to induce abortion after membranes have ruptured. [Pg.241]

The major classical drug target in prostaglandin metabolism is cyclooxygenase, which occurs in several isoforms Cox-1, Cox-2, and apparently in some mammals Cox-3. This is due to the central role of its product prostaglandin H2 as a precursor of multiple eicosanoid mediators (Figure 12.4). [Pg.113]

Over the last 50 years there has been a steady evolution in our knowledge of drug-related renal pathology, including the role of prostaglandins in the kidneys and the concept of two cyclo-oxygenase isozymes. In the 1960s a distinct clinical entity was identified, separate from... [Pg.2681]

A significant stimulus to this search was the observation that prostaglandins play a major role in the inflammatory processes. Drugs such as a.spirin and indomcthacin inhibit prostaglandin synthesis in several tissues." " Furthermore, almost all classes of NSAIDs strongly inhibit the conversion ofarachidonic acid into pnistaglandin This... [Pg.754]


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