Metabolism prostaglandin

Lundholm, E. (1997). DDE induced eggshell thinning in birds effects of p,p -iyDE on the calcium and prostaglandin metabolism of the eggshell gland. Comparative Biochemistry and Physiology 118C, 113-128. 

Free radicals are by-products of prostaglandin metabolism and may even regulate the activity of the arachidonate pathway. Arachidonic acid, released from lipids as a result of activation of phospholipases by tissue injury or by hormones, may be metabolized by the prostaglandin or leu-kotriene pathways. The peroxidase-catalysed conversion of prostaglandin G2 to prostaglandin H2 (unstable prostanoids) and the mechanism of hydroperoxy fatty acid to the hydroxy fatty acid conversion both yield oxygen radicals, which can be detected by e.s.r. (Rice-Evans et al., 1991). 

Di Marzo V, Cimino G, Sodano G, Spinella A, Villani G, A novel prostaglandin metabolic pathway from a marine mollusc prostaglandin 1,15-lactones. 7th Internation Conf, on Prostaglandins and related compounds, 28 May-1 June 1990, Florence, Italy, p 13... 

Baker ME. Sequence analysis of steroid-and prostaglandin- metabolizing enzymes application to understanding catalysis. Steroids 59 1994 248-258. 

The major classical drug target in prostaglandin metabolism is cyclooxygenase, which occurs in several isoforms Cox-1, Cox-2, and apparently in some mammals Cox-3. This is due to the central role of its product prostaglandin H2 as a precursor of multiple eicosanoid mediators (Figure 12.4). 

Figure 12.16. Omega-3 fatty acids and their relevance to prostaglandin metabolism, a Omega-3 nnsatnrated fatty acids are derived from linoleic acid by a special desatnrase fonnd in plants bnt not in mammals. They are particnlarly common in cold-waterfish. b The different nnmbers and positions of donble bonds persist in the eicosanoids derived from different fatty acid precnrsors, giving rise to different homologons derivatives. This is shown here for prostaglandin E. c Biological activity of the eicosanoids derived from eicosapentanoic acid (EPA).

Olsen UB,Ahnfelt-Ronne I. Renal cortical blood redistribution after bumetanide related to hterogenicity of cortical prostaglandin metabolism in dogs. Acta Physiol Scand 1976 97 251-257. 

Reddy, CC Pennsylvania State University Antioxidant effects on prostaglandin metabolism, lipid peroxidation and Immunologic defense CRIS/UDSA2001... 

The alterations produced by THC and other cannabinoids in biogenic amine levels as well as on uptake, release and synthesis of neurotransmitters and effects on enzymes have been the subject of numerous investigations (for reviews see [8,52,55,114,115]). It is beyond the scope of the present summary to try to analyse and put into a proper perspective the wealth of data published so far. It is our subjective view that the mode of action of cannabi-mimetic compounds is somehow directly associated with prostaglandin metabolism (see, in particular, the series of papers by Burstein [115,116]), and/or reduction of hippocampal acetylcholine turnover observed in rats [117,118]. The latter effect is enantiospecific and follows the known SAR of the cannabinoids. This in vivo selectivity of action suggests that the THC may activate specific transmitter receptors which indirectly modulate the activity of the cholinergic neurons in the septalhippocampal pathway. 

Hoeeobin DF (1990) Effects of lithium on essential fatty acid and prostaglandin metabolism. In Bach RO and Gallicchio VS, eds. Lithium and Cell Physiology, pp. 137-149. Springer-Verlag, New York. 

Arisaka, M., Arisaka, O., and Yamashiro, Y., Fatty acid and prostaglandin metabolism in children with diabetes meUitus. II. The effect of evening primrose oil supplementation on serum fatty acid and plasma prostaglandin levels. Prostaglandins Leukot. Essent. Eatty Acids 1991, 43, 197-201. 

There are six major classes of the human cytosolic GST enzymes, namely, alpha, mu, omega, pi, theta, and the newly discovered zeta class (Mannervik et al., 2005). The sigma class is involved in prostaglandin metabolism (isomerization of PGH2 to PGD2) (Jowsey et al., 2001). Kappa class enzymes are expressed in... 

Another transformation which has recently been reported is the conversion of PGAi to PGBi by an isomerase found in the cat [196]. Since the PGB s have very weak biological activity this may provide yet another means of prostaglandin metabolic inactivation. 

Limas, C., Goldman, P Limas, C.J. and Iwai, J. (1981). Effect of salt on prostaglandin metabolism in hypertension-prone and resistant Dahl rats. Hypertension, 3, 219-224... 

I. Prostaglandins - Metabolism - Addresses, essays, lectures. I. Pace-Asciak, C. (Cecil) II. Granstrom, E. (Eli.sabeth) III. Series. (DNLM I. Prostaglandins. 2. Thromboxanes. 3. Lipoxygenases. W1 NE372F v. 5/QU 90 P9672a 1983]... 

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