Histaminergic neurotransmission

Hayaishi, O. Huang, Z. L. (2004). Role of orexin and prostaglandin E2 in activating histaminergic neurotransmission. Drug News Perspec. 17, 105-9. 

ROLES OF THE HISTAMINERGIC NEUROTRANSMISSION ON METHAMPHETAMINE-INDUCED LOCOMOTOR SENSITIZATION AND REWARD A STUDY OF RECEPTORS GENE KNOCKOUT MICE... 

Hj receptor This receptor appears to be involved mainly in presynaptic modulation of histaminergic neurotransmission in the central nervous system. In the periphery, it appears to be a presynaptic heteroreceptor with modulatoiy effects on the release of other transmitters (see Chapter 6). 

Ciozapine (Clozaril) Antipsychotic mechanism unclear. Blocks dopamine receptors as well as cholinergic, adrenergic, serotonergic histaminergic neurotransmission. Schizophrenia in those whom traditional antipsychotics have failed or have produced intolerable side effects. Very few extrapyramidal side effects. Potent antimuscarinic effects. Agranulocytosis in 2%. No tardive dyskinesia or increased prolactin release. 

The triazolopyridines trazodone and nefazodone are antagonists at the 5-HT2 receptor and inhibit the reuptake of 5-HT. They can also enhance 5-HT1A neurotransmission. They have negligible affinity for cholinergic and histaminergic receptors. 

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