Renal Pathology

The cysts involve less than 10% of nephrons, but they gradually expand and compress the rest of the kidney, interfering with its function. This is the reason why kidney function can remain normal for many years. 

Children affected more frequently than adults  

Occurs 2-4 weeks after a streptococcal infection of the throat or skin 

Organism fj-hemolvtic group A streptococci May be caused by other bacteria, viruses, and parasites and systemic diseases (SLE and polyarteritis nodosa [PAN]) 

Electron microscopy subepithelial (humps) immune complex deposits 

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Segerer S, Alpers CE. Chemokines and chemokine receptors in renal pathology. Curr Opin Nephrol Hypertens 2003 12 243-249. 

Renal Pathology and the Proximal Tnbniar CeU for Therapentic Intervention... 

Use of Enterosgel for treatment of renal pathologies is of particular interest A 2-week administration of Enterosgel had positive influence on me mdices of kidney function and survival of rats wim a glycerol model of renal insufficiency (Table 21.6) [35],... 

Corn oil Maternal toxicity (reduced body weight gain, food consumption, and renal pathology) and reduced pup viability in rat reproduction toxicity study... 

Berl, T., Bonventure, J.V. (1998). In Atlas of Diseases of Kidney (R.W. Schrier, ed.). Blackwell Publishing, Philadelphia, USA. Brown, T.P., Fletcher, O.J., Osuna, O. et al. (1987). Microscopic and ultrastmctural renal pathology of oosporein-induced toxicosis in broiler chicks. Avian Dis. 31(4) 868-77. 

Morrow, C.M., Valli, V.E., Volmer, P.A. et al. (2005). Canine renal pathology associated with grape or raisin ingestion 10 cases. J. Vet. Diagn. Invest. 17(3) 223-31. 

Over the last 50 years there has been a steady evolution in our knowledge of drug-related renal pathology, including the role of prostaglandins in the kidneys and the concept of two cyclo-oxygenase isozymes. In the 1960s a distinct clinical entity was identified, separate from... 

Antibodies to the Ro(SSA) cellular antigen (244,397) and circulating cryoglobulins (244) are risk factors for adverse reactions to penicillamine. AntiRo (SSA) antibodies characterize a distinct group of patients with rheumatoid arthritis who are almost exclusively female, express more activated B cell function, have a high prevalence of Sjogren s features, and commonly develop adverse reactions to penicillamine. Rashes and febrile reactions were especially associated with anti-Ro(SSA) antibodies, and renal pathology was more frequent in men (244). 

Nakano M, Ueno M, Nishi S, Shimada H, Hasegawa H, Watanabe T, Kuroda T, Sato T, Maruyama Y, Arakawa M. Analysis of renal pathology and drug history in 158 Japanese patients with rheumatoid arthritis. Clin Nephrol 1998 50(3) 154-60. 

Gavrilov V, Yermiahu T, Gorodischer R. Renal pathology and retinol status in multiple myeloma patients. Kidney int. 2006 Jan 69(1) 173-7. 

Verroust PJ, Birn H, Nielsen R, Kozyraki R, Christensen El, The tandem endocytic receptors megalin and cubilin are important proteins in renal pathology. Kidney Int, 2002 62 745-56. 

Rush GF, Heim RA, Ponsler GD, EngelhardtJ. Cephaloridine-induced renal pathological and biochemical changes in female rabbits and isolated proximal tubules in suspension.Toxicol Pathol 1992 20(2) 155-168. 

Antopol W RH. Urolithiasis and renal pathology after oral administration of 2-sulfanilylamino (sulfapyridine).. Proc Soc Exp Biol Med. 1939 40 428-30. 

Colvin RB EL. Interstitial Nephritis. ln Tisher CC BB, ed. Renal Pathology. 2nd ed. Philadelphia Lippincott 1994 723-68. 

Alendronate therapy of a patient with chronic lymphocytic leukaemia has been associated with the onset of acufe granulomatous interstitial nephritis, a relatively rare renal pathology primarily caused by adverse drug reactions [27]. In this case, treatment with oral alendronate was initiated 2 weeks before... 

Department of Pathology, Renal Pathology Laboratory, Columbia University, New York, NY... 

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