Prostaglandins curcumin

Ireson, C. et al.. Characterization of metabolites of the chemopreventive agent curcumin in human and rat hepatocytes and in the rat in vivo, and evaluation of their ability to inhibit phorbol ester-induced prostaglandin E2 production. Cancer Res., 61, 1058, 2001. 

Lev-Ari S, Maimon Y, Strier L, Kazanov D, Arber N. 2006a. Down-regulation of prostaglandin E2 by curcumin is correlated with inhibition of cell growth and induction of apoptosis in human colon carcinoma cell lines. J Soc Integr Oncol 4 21-... 

The anti-inflammatory activity of curcumin and its derivatives is associated with the hydroxyl and phenol groups in the molecule, which are also essential for the inhibition of prostaglandins, PG synthetase and leucotriene synthesis (LT) (Kiuchi et al., 1982, 1992 Iwakami, et al, 1986). Claeson et al. (1993, 1996) suggested that the antiinflammatory action and the antiparasitic activity were associated with the (3-dicarbo-nylic system with conjugated double bonds (dienes) (Araujo et al., 1998, 1999). The better skin penetration and lipophylicity is attributed to the presence of a diene ketone system. Calebin-A, a novel curcuminoid isolated from turmeric, protects neuronal cells from (3-amyloid insult. The hydroxy group at para-position of this compound is most critical for the expression of biological activity (Kim et al., 2001). 

Srivastava, K.C., Bordia, A., and Verma, S.K., Curcumin, a major component of food spice turmeric (Curcuma longa), inhibits aggregation and alters eicosanoid metabolism in human blood platelets. Prostaglandins Leukot. Essent. Fatty Acids, 52 (4), 223-227, 1995. 

Fig. 1. Inhibitory effect of apigenin, quercetin, naringenin, curcumin and resveratrol on the prostaglandin (PG)E2 production of the macrophage stimulated by lipopolysaccharide (LPS). Source Reference 23.

Fan Zhang at Cornell University in New York and Ajay Goel at the University of California in San Diego found that curcumin, the yellow dye in turmeric (Curcuma longa), inhihits in a concentration- and time-dependent manner the expression of cyclooxygenase-2 and the formation of prostaglandin E2 (PGE2) (Fig. 5.79 and Fig. 5.80). [165,166]... 

COX-2 is an enzyme that is crucial finr the thesis of prostaglandins during inflammation, and is expressed in macrqphages upon stunulaticm with LPS, TNFa, and IL-ip. The effect of curcumin on the gene eiqn essimi of COX-2 was examined. Lhif tunately, unlike TNFa and IL-ip, COX-2 mRNA could... 

The action of curcumin includes those of the commonly used nm-steroidal anti-inflammatoiy drugs (NSAIDs). The anti-inflammatiny actim of aspirin and sodium salicylate is through the inhibition of prostaglandin thesis, via a direct inhibition of the COX enzymes. Curcumin inhibits COX-2 at both the gme expression and tiie enzyme activity levels. At a concentration of 100 pM, it substantially inhibits the mzyme activity of lipoxygmase and... 

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