Prostaglandin E synthase

Thoren, S., Weinander, R., Saha, S. et al. Human microsomal prostaglandin E synthase-1 purification, functional characterization, and projection structure determination. /. Biol. Chem. 278 22199-22209,2003. 

PGH2 + Enzyme (microsomal prostaglandin E synthase, mPGES) PGE2... 

This glutathione-dependent enzyme [EC 5.3.99.3], also known as prostaglandin E synthase, prostaglandin H2 E isomerase, and endoperoxide isomerase, catalyzes the... 

Yoshimatsu K, Altorki NK, Golijanin D, Zhang F, Jakobsson PJ, Dannenberg AJ, Subbar-amaiah K. Inducible prostaglandin E synthase is overexpressed in non-small cell lung cancer. Clin Cancer Res. 7 (2001) 2669-2674. 

N.A., Ziecik, A.J. 2006. Molecular cloning and spatiotemporal expression of prostaglandin F synthase and microsomal prostaglandin E synthase-1 in porcine endometrium. Endocrinology 147 210-221. 

Meadows, I. W., Pitzer, B., Brockman. D. E., and Myatt, L. (2004). Differential localization of prostaglandin E synthase isoforms in human placental cell types. Placenta 4, 259-265. 

Prostaglandin E synthase (PGES) catalyzes the isomerization of PGH to PGE. Three types of PGES have been characterized the cytosolic PGES (cPGES) and... 

Jakobsson, P. J., S. Thoren et al. 1999. Identification of human prostaglandin E synthase A microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target. Proc Natl Acad Sci USA 96(13) 7220-7225. 

Mancini, J. A., K. Blood et al. 2001. Cloning, expression, and up-regulation of inducible rat prostaglandin e synthase during hpopolysaccharide-induced pyresis and adjuvant-induced arthritis, 276(6) 4469-4475. 

Samuelsson, B., R. Morgenstem et al. 2007. Membrane prostaglandin E synthase-1 A novel therapeutic target. 59(3) 207-224. 

Stichtenoth, D. O., S. Thoren et al. 2001. Microsomal prostaglandin E synthase is regulated by proinflammatory cytokines and glucocorticoids in primary rheumatoid synovial cells. JJmmun 167(1) 469—474. 

Tanikawa, N., Y. Ohmiya et al. 2002. Identification and characterizahon of a novel type of membrane-associated prostaglandin E synthase. Riochem Riovhvs Res Commun 291(4) 884-889. 

Scheme 14.29 Combined DoM-Suzuki-Miyaura cross-coupling-DreM. Synthesis of prostaglandin E synthase-l inhibitor MK-7285 143 [143].

Engblom, D, Saha, S, Engstrom, L, Westman, M, Audoly, LP, Jakobsson, PJ and Blomqvist, A (2003) Microsomal prostaglandin E synthase-1 is the central switch during immune-induced pyresis. Nature Neurosci, 6, 1137-1138. 

Forsberg, L, Leeb, L, Thoren, S, Morgenstem, R and Jakobsson, P (2000) Human glutathione dependent prostaglandin E synthase gene structure and regulation. FEBS Lett, 471, 78-82. 

Murakami, M, Nakatani, Y, Tanioka, T and Kudo, I (2002) Prostaglandin E synthase. Prostaglandins Other Lipid Mediat, 69, 383-399. 

COX-2 and prostaglandin E synthase (PGES) are colocalized in symptomatic lesions. Synthesis of COX-2 and PGES by activated macrophages is associated with acute ischemic syndromes, possibly through MMP-induced plaque rupture (539). 

Cipollone F, Prontera C, Pini B, et al. Overexpression of functionally coupled cyclooxygenase-2 and prostaglandin E synthase in symptomatic atherosclerotic plaques as a basis of prostaglandin E(2)-dependent plaque instability. Circulation 2001 104 921-927. 

Prostaglandin E synthase (also called prosta-glandin-Hj E-isomerase), which requires glutathione, also acts on PGGj albeit more slowly. Prostaglandin Fj may also be synthesized by the action of prostaglandin F synthase on PGDj or by... 

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