1 - propylamine, from

The difference in the results of TPD of 1-propylamine from the BETA sample prior to and after SSIE indicated a 92.7% consumption of the Bronsted acid sites. 

Scheme 11.40. Synthesis of 1-arylcyclo-propylamines from aromatic nitriles by reaction with diethylzinc in the presence of MeTi(0/Pr)3 and NaO/ Pr [138].

FIGURE 10 Chiral recognition model showing three simultaneous bondings between (5)-methyl-X-(2-naphthyl)alaninato and (5)-iV-(3,5-dinitrobenzoyl)leucine n-propylamine. (From Ref. 9.)... 

Amides are more conveniently reduced with lithium aluminum hydride in ether solution to yield amines with the same carbon content, e.g, tri-ethylamine from N,N-diethylacetamide (50%) and ethyl-n-propylamine from N-ethylpropionamide (53%). ° The same conversion has been accomplished by an electrolytic reduction. ... 

The Tcrom ester is prepared from the cesium salt of an N-protected amino acid by reaction with 2-(trifluoromethyl)-6-chromylmethyl bromide (DMF, 25°, 4 h, 53-89% yield). Cleavage of the Tcrom group is effected by brief treatment with n-propylamine (2 min, 25°, 96% yield). It is stable to HCl/dioxane, used to cleave a BOC group. ... 

Tri-n-propylamine [102-69-2] M 143.3, b 156.5 , d 0.757, n 1.419, pK 10.66. Dried with KOH and fractionally distd. Also refluxed with toluene-p-sulfonyl chloride and with KOH, then fractionally distd. The distillate, after addn of 2% phenyl isocyanate, was redistd and the residue fractionally distd from sodium. [Takahashi et al. J Org Chem 52 2666 1987.]... 

The Leuckart synthesis has been applied successfully in the thiophene series, iV,A -Dimethyl thenylamine and A, A -diethyl thenylamine were obtained from 2-thiophenealdehyde and the appropriate for-mamide. Seven -(2-thienyl)- -arylethylamine hydrochlorides have been prepared from the corresponding ketones in about 40-60% yields and, finally, A -methyl-1-(3-thienyl)-2-propylamine was obtained in 48% yield in the Leuckart reaction from 3-thienylace-tone, methylamine, and formic acid. ... 

A search has not been made for products of displacement of halogen from the benzo-ring in polyhalo compounds, but it is clear that the major mono-substitution occurs in the azine ring. For example, 2,6- and 2,7-dichloroquinoxalines give 70-80% of the 2-amination product with )S-diethylaminoethylamine (150°, 2 hr) or y-(l-piperidyl)-propylamine (220°, 2 hr). 2,3,6-Trichloroquinoxaline gives with... 

The irradiation of 3,5-diphenylisoxazole in the presence of propylamine gave a mixture of 2,5-diphenyloxazole (20%) and A-propyl-2,5-diphenylimidazole (1%). The same distribution of the products was obtained starting from the azirine 46 (75T785). 

Pinene-nitrosochloride forms a series of compounds with various bases, such as propylamine, amylamine, benzylamine, etc., known as pinene-nitrolamines. If two molecules of benzylamine in alcoholic solution be allowed to act on one molecule of pinene-nitrosochloride, pinene nitrol-benzylamine separates on the addition of water, and on recrystallisation from a mixture of ether and alcohol, forms beautiful... 

The 1-(o-chlorophenyl)-2-methyl-2-propylamine hydrochloride is prepared by adding ethanolic hydrogen chloride to an ice-cold solution of the free base in ethanol the desired salt precipitates and is recrystallized from ethanol, MP 245° to 246°C. 

Propanol with magnesium in reduction of chlorobenzene, 47, 104 Propionyl fluoride, 46, 6 n Propylamine, 46, 85 n Propylhydrazine, 46, 85 C ( Propyl) N phenylmtrone, genera tion from phenylhydroxylamme and n butyraldehyde, 46, 97 Purification of tetrahydrofuran (Warning), 46,105 4H Pyran 4-one, 2 6 dimethyl 3,5 diphenyl, 47, 54... 

A synthetically useful virtue of enol triflates is that they are amenable to palladium-catalyzed carbon-carbon bond-forming reactions under mild conditions. When a solution of enol triflate 21 and tetrakis(triphenylphosphine)palladium(o) in benzene is treated with a mixture of terminal alkyne 17, n-propylamine, and cuprous iodide,17 intermediate 22 is formed in 76-84% yield. Although a partial hydrogenation of the alkyne in 22 could conceivably secure the formation of the cis C1-C2 olefin, a chemoselective hydrobora-tion/protonation sequence was found to be a much more reliable and suitable alternative. Thus, sequential hydroboration of the alkyne 22 with dicyclohexylborane, protonolysis, oxidative workup, and hydrolysis of the oxabicyclo[2.2.2]octyl ester protecting group gives dienic carboxylic acid 15 in a yield of 86% from 22. 

The submitters used tri-Ji-propylaniine obtained from Aldrich Chemical Company, Inc., and the checkers used tri-n-propylamine obtained from Wako Pure Chemical Industries, Ltd., Japan. Both groups stored the reagent over Linde type 4A molecular sieves prior to use,... 

N-Methyl-N-f2-Nitroxy propyl) Nitramine. (Me2NENA N-(2-NitroxypropyI) methyl nitramine. (02N)N(CH3).(CH2CH(0N02).CH3, mw 179.16, N 23.46%, OB to C02 -66.80%, pale yellow oil, mp 22—23°, d 1.320g/cc at 25/4°, RI 1.478 at 25°. Prepn from 2-hydroxy-propylamine after nitration with 98% nitric acid at 10° by reaction of the amine-nitric acid mixt with acetic anhydride acetyl chloride at 35°. Reaction mixt poured on ice. Yield is 74%. No expl properties listed Reft 1) Beil - not found 2) Blomquist, OSRD 4134, 45 119 (1944)... 

Figure 31-4. Conversion of spermidine to spermine. Spermidine formed from putrescine (decarboxylated L-ornithine) by transfer of a propylamine moiety from...

Oxidative carbonylation generates a number of important compounds and materials such as ureas, carbamates, 2-oxazolidinones, and aromatic polycarbonates. The [CuX(IPr)] complexes 38-X (X = Cl, Br, I) were tested as catalysts for the oxidative carbonylation of amino alcohols by Xia and co-workers [43]. Complex 38-1 is the first catalyst to selectively prepare ureas, carbamates, and 2-oxazolidinones without any additives. The important findings were the identity of the counterion and that the presence of the NHC ligand influenced the conversions. 2-Oxazohdinones were formed from primary amino alcohols in 86-96% yield. Complex 38-1 also catalysed the oxidative carbonylation of primary amines to ureas and carbamates. n-Propylamine, n-butylamine, and t-butylamine were transformed into the... 

A variety of cleavage conditions have been reported for the release of amines from a solid support. Triazene linker 52 prepared from Merrifield resin in three steps was used for the solid-phase synthesis of aliphatic amines (Scheme 22) [61]. The triazenes were stable to basic conditions and the amino products were released in high yields upon treatment with mild acids. Alternatively, base labile linker 53 synthesized from a-bromo-p-toluic acid in two steps was used to anchor amino functions (Scheme 23) [62]. Cleavage was accomplished by oxidation of the thioether to the sulfone with m-chloroperbenzoic acid followed by 13-elimination with a 10% solution of NH4OH in 2,2,2-trifluoroethanol. A linker based on l-(4,4 -dimethyl-2,6-dioxocyclohexylidene)ethyl (Dde) primary amine protecting group was developed for attaching amino functions (Scheme 24) [65]. Linker 54 was stable to both acidic and basic conditions and the final products were cleaved from the resin by treatment with hydrazine or transamination with ra-propylamine. 

A number of amidines have anthelmintic activity. Bunamidine (25), indicated for treatment of human pinworm infestations, is prepared from a-naphthylhexyl-ether (23) by Friedel-Crafts type reaction with cyanogen bromide and aluminum chloride to give nitrile (24). This, then, is reacted with the magnesium bromide salt of di-n-propylamine leading to the naph-thamidine structure (25). -... 

Figure 10 Separation of ABEI-DSC-derivatized n-octylamine (2) and n-propylamine (3) with ECL detection. Remaining ABEI (1) and ABEI DSC (not shown) are also detected. Conditions 20% methanol in 5 mM sodium borate separation buffer, pH 10.9 5-s injection at 25 kV, 1.0 X 10 6 for each labeled amine 25-kV separation potential 10-mm platinum wire electrode. (From Ref. 85, with permission.)...

Table 9.5 Percentage conversion from allylamine (1.8 mmol) to propylamine obtained with cyclodextrin (CD)-modified Pt and Pd nanoparticles under 1.0 atm H2(g) at room tempera ture in D20 solution (2.0 ml ). (Reprinted with permission of the Royal Society of Chemistry [69])...

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