Propyl thiol, oxidation

A recent study on the reactivity of the parent benzo-l,2-dithiolan-3-one 1-oxide 79a (R = R = H) and o- and /i-substituted derivatives 79b-g with -propyl thiol in acetone/water mixture (7/3) was prompted (Table 5) by the observation that the DNA-cleaving activity and antitumor activity of leinamycin 5 depends, in part <2005JOC6968>, on initial thiol attack on its l,3-dioxo-l,2-dithiolane functionality. Experimental results have proved that the presence of chlorine as an electron acceptor in the /i ra-position relative to the sulfmyl sulfur S-1 of precursor 79e and ortho-substituents with lone electron pairs in the case of precursors 79b and 79d are responsible for increased product formation of polysulfanes 80 and 81. A rationale in terms of substituent effects, operating through-space and through-bond of the intermediates a and b, respectively, was suggested. In other words, the reaction is favored by ortho-substituents with lone pair electrons next to the dithiolanone-oxide (S-1) reaction center or a decrease of the electron density at the /i ra-position. 

The emeraldine base form of PANI (compound 1) was prepared by chemical oxidation method described by MacDiarmid and co-workers [33]. The PANI was extracted with THF until the extract was colorless. The dried PANI (0.25 g) reacted with 3-chIoropro-pyl thiol (0.5 ml) and ferric chloride (0.01 g) in anhydrous dimethyl sulfoide at 81°C for 24 hr. The black solution (propyl thiol substituted PANI) was precipitated with IM HCl, a dark green to black precipitate was formed the filtrate was greenish blue the precipitate was washed with IM HCl, then with acetonitrile. The precipitate (propyl thiol substituted PANI) was dried under continuous vacuum for 48 hr. 

The cyclic voltammogram of Propyl thiol polyaniline was obtained in 0.5M HCl solution using BAS Instrument Model 100, a thin film was smeared on indium tin oxide (ITO) glass slide, the working electrode, a platinum wire counter electrode, a platinum wire counter electrode, and Ag/AgCl reference electrode. 

Aliphatic and aromatic thiols react with pyridine 1-oxides and their quaternary derivatives by Type A, B and/or C pathways, but no such reactions have been reported for pyridine or its salts. 1-Ethoxypyridinium ethosulfate reacts with sodium n-propanethiolate to give mainly pyridine (Type A), and a 6 1 mixture of 3- and 4-pyridyl propyl sulfides (equation... 

Pr Pro ptz pvp py pyca pycaH pyo pyr pys pySH pySSpy iso-propyl = 2-propyl proline phenothiazine polyvinyl pyridine pyridine pyridine-2-carboxylato(l -) pyridine-2-carboxylic acid pyridine iV-oxide pyrimidine pyridine-2-thiolato(l -) pyridine-2-thiol 2,2 -bis(pyridyl) disulfide... 

The autoxidation of simple thiols is also very dependent on the basicity of the solvent and high polar solvents such as dimethylformamide [108— 110] and tetramethylguanidine [108] accelerate the reaction. The first detailed investigation was carried out with the thiols dissolved in aqueous sodium hydroxide solution [111]. Although the apparatus was crude, stoichiometric conversion to the disulphide was observed with the ease of oxidation of different thiols decreasing in the order n-propyl > n-butyl > n-amyl > benzyl > phenyl. 

Thiols with oxidized side-chains Structural class 1 Propyl 2- 1667 19788-50-2 No Yes. The NOEL of 0.7 mg/kg bw per day See notes 2 No safety... 

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