Propionamides

Primary amides condense with hydroxybenzaldehydes in a manner similar to amines. This reaction is often conducted in the presence of sodium acetate or an organic base such as pyridine. For example, the reaction of sahcylaldehyde and propionamide produces sahcyhdene propionamide (58). 

Either of these stmctures can react further with caustic to give the acrylamide reactive group, dye—NHCOCH=CH2, which bonds with cellulose to give the more stable P-propionamide derivative. 

The propionamide can be dried over CaO. H2O and unreacted propionic acid were removed as their xylene azeotropes. It was vacuum dried. Material used as an electrolyte solvent (specific conductance less than 10 ohm cm" ) was obtained by fractional distn under reduced pressure, and stored over BaO or molecular sieves because it readily absorbs moisture from the atmosphere on prolonged storage. [Hoover Pure Appl Chem 37 581 I974 Recommended Methods for Purification of Solvents and Tests for Impurities, Coetzee Ed., Pergamon Press, 1982.]... 

Propionamide [79-05-0] M 73,1, m 79.8-80.8 , pK -0.9 (Ho scale, aq H2SO4). Crystd from acetone, benzene, CHCI3, water or acetone/water, then dried in a vacuum desiccator over P2O5 or cone H2SO4. 

Preparation of Di-(0-Pheny/-a,a-Dimethylethyl)Urea 3.5 grams of a,a-dimethyl-(3-phenyl-propionamide in 420 cc of water was added to a solution of 87.5 grams of potassium hydroxide and 35 grams of bromine in 350 cc of water. After 2 hours at 60°C, the product was obtained on crystallization from ethanol, melting at 184°C. 

Acrylamide impurities (dissolve the sample in a minimum amount of methanol) also separate formamide, acetamide, dimethylformamide, jV-methylacetamide, propionamide, N,N-dimethylacetamide... 

Isomers are, of course, possible when the equatorial ligand lacks a plane of symmetry, as in the corrinoids [see (HI)]. All the acetamide side chains project to one side of the corrin ring, which we shall call the upper side, and all the propionamide side chains and the nucleotide side chain to the lower side. Isomers are then theoretically possible whenever the two axial ligands are different, and their existence has been shown experimentally for corrinoids where one axial ligand is CN , Me, or Et and the other is H2O or is absent [for further details see Section 8.2 of ref. (136)]. Salen and BAE also show minor deviations from planarity due to the bending of the two halves (mentioned above in Section II,B,2) and to torsion about the C—C bonds in the ethylene bridge (see references in Table I), but these are not expected to give rise to separable isomers. 

Purification of 2-(4 -[ I]iodo-biphenyl-4-sulfonylamino)-3-(l//-indol-3-yl)-propionic acid and 2-(4 -[ I]iodo-biphenyl-4-sulfonylamino)-3-(lff-indol-3-yl)-propionamide... 

Figure 5-4. 2-Bromo-2-bromomethylglutaronitrile, 2,2-dibromo-3-nitrilo-propionamide, 1,2-dimethyl-5-nitro-1 H-imidazole, 4,4-dimethyl-2-oxazo-lidinone, dimethylaminopropyl acrylamide, dimethylaminopropyl methacrylamide, or dimethylaminopropyl acrylamide, 5,5-dimethylhydantoin, dimethylurea.

Tolerance levels in or on coffee beans, established under the Federal Food, Drug, and Cosmetic Acts, include values for glyphosate and its sulfinyl and sulfonyl metabolites,191 and N,N-dimethyl-2-(l-naphthalenyloxy)propionamide.192... 

Anon., Tolerances for pesticide chemicals in or on raw agricultural commodities N,N-diethyl-2-(l-naphthalenyloxy)-propionamide, Fed. Regist., 46, 47547, 1981. 

A third factor has been suggested for enhanced resolution of the Co(II) ESR spectrum, because in the enzyme the movement of the acetamide and propionamide side-chains of the corrin ring will be restricted. This restriction would diminish fluctuations in the magnetic environment of the cobalt. 

Eudy, L. W. Walla, M. D. Hudson, J. R. Morgan, S. L. Fox, A. Gas chromatog-raphy-mass spectrometry studies on the occurrence of acetamide, propionamide and furyl alchohol in pyrolysates of bacteria, bacteria fractions and model compounds. J. Anal. Appl. Pyrolysis 1985, 7, 231-247. 

Figure 8.3 Preparation of (R)-2,2-HTFMPS and (S)-2,2-HTFMPA from racemic 3,3,3-trifluoro-2-hydroxy-2-methyl-propionamide using Klebsiella oxytoca PRS1...

Figure 8.4 Nitrilase-catalyzed conversion of (5)-3-(thiophen-2-ylthio)butanenitri le to (S)-3,3,3-trifluoro-2-hydroxy-2-methyl-propionamide, an intermediate in the synthesis of carbonic anhydrase inhibitor Dorzolamine ...

Free radical polymerization combined with anionic ring polymerization was employed for the synthesis of poly(N-vinylpyrrolidone)-fr-poly(D,L-lactide), PVP-fr-PDLLA, as shown in Scheme 49 [121]. The free radical polymerization of VP was conducted using 2,2/-azobis[2-methyl-M-(2-hydroxyethyl)propionamide] as the initiator, isopropyl alcohol and 2-... 

AMCA-HPDP is N-[6-(7-amino-4-methylcoumarin-3-acetamido)hexyl]-3 -(2 -pyridyldithio) propionamide. It is formed from AMCA plus a 1,6-diaminohexyl spacer off the carboxylate that has been additionally modified at its terminal end with SPDP (Chapter 5, Section 1.1). 

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