Propecia - Finasteride

U.S. product circular for Propecia (finasteride 1 mg tablets). (1999). In Physicians Desk Reference, 53rd ed., pp. 1877-1880. Medical Economics Co, Montvale, NJ. 

Propecia Finasteride 1 mg Tablet Male pattern hair loss A specific inhibitor of steroid type II 5 a-reductase Lactose monohydrate, MCC, pregelatinized starch, sodium starch glycolate, docusate sodium, magnesium stearate, Hypromellose 2910 Merck Co. 

Development difficulties. Propecia (finasteride) is a synthetic steroid that functions as a competitive and specific inhibitor of 5a-reductase, the enzyme responsible for the synthesis of dihydrotestosterone from testosterone. 

The truth is that only Rogaine (minoxidil) rubbed into the scalp, and Propecia (finasteride) taken orally, have shown any hair-growing effects, but these effects are not very impressive. The Bald-Headed Men of America — headquartered, appro-... 

Among the candidates considered for development in this series was the t-Bu amide which was subsequently given the name finasteride and became the active ingredient in both PROSCAR and PROPECiA (Figure 3.2). Section 3.1 will tell the story of the development of a manufacturing process for finasteride. As in most programs at Merck, dmg candidates showing potential for improved performance over the lead compound were approved for development as the lead... 

Currently, bupropion (Zyban, GlaxoSmithKline) is the only approved drug for helping cease cigarette smoking, and finasteride (Propecia, Merck) has been approved by the Food and Drug Administration (FDA) for the treatment of male baldness. 

Such an inhibitor is finasteride, marketed as Proscar for treatment of BPH and Propecia for treatment of male-pattern baldness. 

Dibucaine (Nupercainal) Doxepin, Topical (Zonalon, Prudoxin) Econazole (Spectazole) Efalizumab (Raptiva) Erythromycin, Topical (A/T/S, Eryderm, Erycette, T-Stat) Erythromycin Benzoyl Peroxide (Benzamycin) Finasteride (Propecia) Fluorouracil, Topical [5-FU] (Efudex) Gentamicin, Topical (Garamycin, G-Mycitin)... 

Finasteride (Propecia) is a 5K-reductase inhibitor that blocks the conversion of testosterone to dihydrotestosterone (see Chapter 40), the androgen responsible for androgenic alopecia in genetically predisposed men. Oral finasteride, 1 mg/d, promotes hair growth and prevents further hair loss in a significant proportion of men with androgenic alopecia. 

Chapter 6. Cosmeceuticals Isotretinoin (Accutane ), Tazoratene (Tazorac ), Minoxidil (Rogaine ), and Finasteride (Propecia )... 

USAN Finasteride Trade Name- Propecia Merck... 

Kim BJ, Kim YJ, Ro BI. Two cases of reversible bilateral painful gynecomastia induced by 1 mg oral finasteride (Propecia). Korean J Dermatol 2003 41 232-4. 

Finasteride (Propecia) is a 5 -reductase inhibitor that blocks the conversion of testosterone to dihydrotestosterone, the androgen responsible for androgenic alopecia in genetically predisposed men. Oral finasteride, 1 mg/d, promotes hair growth and prevents further hair loss in a significant proportion of men with androgenic alopecia. Treatment for at least 3-6 months is necessary to see increased hair growth or prevent further hair loss. Continued treatment with finasteride is necessary to sustain benefit. Reported side effects include decreased libido, ejaculation disorders, and erectile dysfunction, which resolve in most men who remain on therapy and in all men who discontinue finasteride. 

Finasteride (2) Propecia Merck Androgenetic alopecia (men only) 1 mg tablet 1 tabletlday Prescription... 

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