PROPECIA

Among the candidates considered for development in this series was the t-Bu amide which was subsequently given the name finasteride and became the active ingredient in both PROSCAR and PROPECiA (Figure 3.2). Section 3.1 will tell the story of the development of a manufacturing process for finasteride. As in most programs at Merck, dmg candidates showing potential for improved performance over the lead compound were approved for development as the lead... [Pg.77]

Currently, bupropion (Zyban, GlaxoSmithKline) is the only approved drug for helping cease cigarette smoking, and finasteride (Propecia, Merck) has been approved by the Food and Drug Administration (FDA) for the treatment of male baldness. [Pg.372]

Such an inhibitor is finasteride, marketed as Proscar for treatment of BPH and Propecia for treatment of male-pattern baldness. [Pg.272]

Androgenetic alopecia (Propecia only) Treatment of male pattern hair loss (vertex and anterior mid-scalp) in patients between 18 and 41 years of age. [Pg.239]

Dibucaine (Nupercainal) Doxepin, Topical (Zonalon, Prudoxin) Econazole (Spectazole) Efalizumab (Raptiva) Erythromycin, Topical (A/T/S, Eryderm, Erycette, T-Stat) Erythromycin Benzoyl Peroxide (Benzamycin) Finasteride (Propecia) Fluorouracil, Topical [5-FU] (Efudex) Gentamicin, Topical (Garamycin, G-Mycitin)... [Pg.44]

Proscar (Propecia) 2.8 (0.1) b b An anabolic steroid that acts as a 5-a-ieductase inhibitor responsible for the biotransformation of testosterone to dibydrotestosterone in the skin and prostate gland. [Pg.73]

Finasteride (Propecia) is a 5K-reductase inhibitor that blocks the conversion of testosterone to dihydrotestosterone (see Chapter 40), the androgen responsible for androgenic alopecia in genetically predisposed men. Oral finasteride, 1 mg/d, promotes hair growth and prevents further hair loss in a significant proportion of men with androgenic alopecia. [Pg.1305]

Chapter 6. Cosmeceuticals Accutane , Tazorac , Rogaine , and Propecia ... [Pg.55]

USAN Finasteride Trade Name- Propecia Merck... [Pg.55]

Chou S-Y, Kao S-C, Hsu W-M. Propecia-associated bilateral cataract. Clin Exp Ophthalmol 2004 32 106-8. [Pg.157]

Kim BJ, Kim YJ, Ro BI. Two cases of reversible bilateral painful gynecomastia induced by 1 mg oral finasteride (Propecia). Korean J Dermatol 2003 41 232-4. [Pg.158]

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