1-Propanol, 2-amino-3-phenyl

Dimethyl sulfoxide Methyl sulfoxide (8) Methane, sulfinylbis- (9) (67-68-5) Triethylamine (8) Ethanamine, N,N-diethyl- (9) (121-44-8) (S)-2-Amino-3-phenyl-1 -propanol 1-Propanol, 2-amino-3-phenyl-, L- (8) Benzenepropanol, 2-amino-, (S)- (9) (3182-95-4)... 

Das Antibiotikum Chloromycetin wird durch Bacillus subtilis8, Escherichia coli8,9 und Pseudomonas vulgaris10 zum biologisch inaktiven 2-Amino-3-oxo-3-(4-amino-phenyl)-propanol reduziert unter gleichzeitiger Deacylierung an der Seitenkette ... 

Bielawska A, Greenberg MS, Perry D, Jayadev S, Shayman 156. JA, McKay C, Hannun YA. (lS,2R)-D-erythro-2-(N-Myristoyl amino)- -phenyl-1-propanol as an inhibitor of ceramidase. J. 

Common Name dl-norephedrine hydrochloride 2-amino-1-phenyl-1-propanol hydrochloride... 

With the stcrically constrained /(-amino alcohols N-P asymmetric amplification phenomena were observed similar to the effects found with 3-e.Y0-(dimethylamino)isoborneol (vide supra). Thus, alkylation of benzaldehyde with diethylzinc, catalyzed by a partially resolved catalyst N-P, gives 1-phenyl-1-propanol with an enantiomeric excess, which impressively exceeds the optical purity of the catalyst employed12. 

Photolysis, apparatus for, 55, 17 Phthalimide, N-amino- [ 1//-Isoindole-1,3-(2//)-dione, 2-amino-, 55, 115 Potassium rew-butoxide [2-Propanol, 2-methyl-, potassium salt], 55,12, 13 Potassium iodide, 55, 71 Potassium permanganate [Permanganic acid, potassium salt], 55,68 Propane, 2,2 dimethyl 1 phenyl, 55, 112 Propane, 2 isocyano-2-methyl-, 55, 96... 

L-2-Amino-3-phenyl-propanoll(l Zu einer Losung von 3,5 g (92 mMol) Natriumboranat in 50 ml 50%igem Athanol wird unter Riihren eine Losung von 5 g (22 mMol) L-Phenyl-alanin-athylester-Hydrochlorid in 50 ml... 

H5C6-CO-CH-CHj NHj Cle erythro-2-Amino-1 -phenyl-propanol-Hydrochlorid Na[BH4] 85 191 4... 

H5C6-CO-CH-CH3 H7C3-N-CH3 eryth ro-2-( N-Methyl- N-propyl-amino)-1 -phenyl-propanol-Hydrochlor fd NafBH4J 85 148-149 5... 

Quantitativ verlauft in alkalischer Losung die Reduktion von Cumolhydroperoxid zum 2-Phenyl-propanol-(2)1. Die Reduktion von 2-Nitro-l-thiocyanat-benzolen fiihrt iiber-wiegend zu 2-Amino-1,3-benzothiazolen (s.S. 692)2. Phenylthiocyanat liefert Thiophe-nol1. 

R,2S)-2-[(Ethoxycarbonyl)amino]-l-phenyl-l-propanol [Bronsted Acid Promoted Reduction of an a-Amino Ketone to an Erythro a-Hydroxy... 

R, 25) -2- [(ethoxycarbonyl) amino] -1 -phenyl-1 -propanol [Brdnsted acid promoted reduction of c/-amino ketone to erythro a-hydroxy amine], 124-125... 

Tertiarybutoxycarbonyl (tboc) derivative of 3-phenyl-2-amino-l-propanol... 

FIGURE 1.54 HPLC chromatogram of 2-amino-3-phenyl-l-propanol generated by cleavage of its t-BOC derivative with trifluoroacetic acid and clean-up on strata-X-C. 

Nucleophilic addition of metal alkyls to carbonyl compounds in the presence of a chiral catalyst has been one of the most extensively explored reactions in asymmetric synthesis. Various chiral amino alcohols as well as diamines with C2 symmetry have been developed as excellent chiral ligands in the enantiose-lective catalytic alkylation of aldehydes with organozincs. Although dialkylzinc compounds are inert to ordinary carbonyl substrates, certain additives can be used to enhance their reactivity. Particularly noteworthy is the finding by Oguni and Omi103 that a small amount of (S)-leucinol catalyzes the reaction of diethylzinc to form (R)-l-phenyl-1 -propanol in 49% ee. This is a case where the... 

Hydrolysis products that may form in soil and in microbial cultures include A-phenyl-3-chloro-carbamic acid, 3-chloroaniline, 2-amino-4-chlorophenol, monoisopropyl carbonate, 2-propanol, carbon dioxide, and condensation products (Rajagopal et al., 1984). The reported half-lives in soil at 15 and 29 °C were 65 and 30 d, respectively (Hartley and Kidd, 1987). 

B. 2-(N-Benzyl-N-mesitylenesulfonyl)amino-1-phenyl-1-propanol, 3. A mixture of 2 (16.7 g, 50 mmol), benzyl chloride (6.90 mL, 60 mmol) (Note 1), tetrabutylammonium iodide (200 mg) (Note 1) and potassium carbonate (8.4 g, 60 mmol) in acetonitrile (100 i L) is heated under reflux for 17 hr (Note 4). The cooled mixture is filtered and the salt is washed with diethyl ether (100 mL). The combined organic layers are concentrated and the residue is crystallized from dichloromethane (25 mL) and hexane (100 mL) to give 3 (17.0 g. 80%) (Notes 5, 6). 

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