Proliferation resistance related terms

The terms and definitions used in the design description outline correspond to reference [18]  

The following simple classification, defined in [10], illustrates the design stages of an NPP project. Bullets indicate the items to be defined, determined, completed, achieved or established (whatever is applicable) within each stage. 

Single line flow diagrams for reactor coolant and other main processes (power production), and safety-related systems  

Specific safety features, including accident management  

Overall sizes for main components, long delivery items and buildings  

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Using concentrations of heparin, that are inhibitory to SMC proliferation, causes SM-type a-actin expression to be up-regulated [295,296]. In plasma-derived serum however, heparin is not able to modify a-actin expression, indicating that its action is related to an antiproliferative action [296]. Barzu et al. [297], have isolated in vitro a subpopulation of rat aortic SMC that is heparin-resistant in terms of growth inhibition, but differentiation responsive (increased SM-type a-actin expression) to heparin treatment. This finding is in line with the theory that heparin acts on SMC differentiation and proliferation through distinct pathways. 

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