Progesterone vaginal delivery

Conventional vaginal delivery systems include tablets, foams gels, suspensions, and pessaries. Mucoadhesive gel formulations based on polycarbophil have been reported to remain 3 to 4 days at the vaginal tissue, providing an excellent vehicle for the delivery of progesterone and nonoxynol-9 [66]. 

Because of the beneficial effects of the vaginal delivery of estrogens and progesterone in comparison to their oral delivery, various vaginal preparations (tablets, suppositories, gels, rings) of these agents are now available, for use ... 

Valenta, C., Kast, C. E., Flarich, I., and Bernkop-Schnurch, A. (2001), Development and in vitro evaluation of a mucoadhesive vaginal delivery system for progesterone,/. Controlled Release, 77,323-332. 

Furthermore, vaginal administration of micronized progesterone has been shown to enhance progesterone delivery to the uterus by about 10-fold in comparison to im injection, despite the markedly higher (about 7-fold) circulating drag concentration achieved with im injection. Uterine selectivity after vaginal... 

Liposomes, a novel drug delivery system, are widely applied in the topical treatment of diseases, including vaginal diseases. Their applications in contraceptive systems for the intravaginal administration of progesterone and interferon-a (or metronidazole) for the genital papilloma virus infections were previously reported. 

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