Process-scale applications

A process scale application of Sephacryl S-100 is demonstrated by the polishing of a pharmaceutical in a system of three BPSS columns giving a final bed volume of 2500 liters (Fig. 2.9, page 51). 

JJ Lalonde, C Govardhan, RA Persichetti, Y-F Wang, AL Margolin. Process-scale application of CLECs the processing and economic benefits of using cross-linked enzyme crystals as biocatalysts. Proc. Industrial Biocatalysis InBio 96, Manchester, UK, 1996. 

This nonlinear multicomponent separation technique is eminently suitable for preparative/process scale applications. In displacement chromatography, the competition... 

Process Scale Applications of Pd-Catalyzed -Arylation Reactions... 

It is beyond the scope of this chapter to review the extensive literature available for the use of analytical supercritical fluid chromatography and extraction. However it is important for the reader to appreciate the problems posed by scaling-up the ana-l)dical technique for preparative and process scale applications. 

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