Process random screening

Examination of the various classified listings of herbicides provides iasight iato the processes and approaches that lead to the discovery of new pesticides. The four principal development approaches are random screening, imitative chemistry, testing natural products, and biorational development. 

Three approaches may be taken to discover new herbicides. They are (a) the random screening of chemicals, (b) the use of known herbicides as lead compounds for a synthesis program, and (c) the design of compounds interfering with known metabolic processes - the "rational" approach. There are no publications in the field of herbicide discovery that would suggest that the latter approach has advanced very much beyond the theoretical stage. The second approach, sometimes referred to as the "me-too" approach, has both positive and negative features. The... 

One of the earliest approaches to drug discovery was the random screening process. More recently, significant efforts were directed towards... 

Due to the recommendation that when studying factors one should include all the possible factors that may affect a process, we use two methods in the process of screening them the method of prior ranking of factors and the method of random balance. We may now suggest an optimization research scheme of a multifactor process ... 

Natural sources are still important sources of lead compounds and new drugs. However, the large diversity of potential natural sources in the world makes the technique of random screening a rather hit or miss process. The screening of local folk remedies (ethnopharmacology) offers the basis of a more systematic approach. In the past this has led to the discovery of many important therapeutic agents, for example, the antimalarial quinine from cinchona bark, the... 

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