Process Development Critical Factors for the Application of Catalysts

Process Development Critical Factors for the Application of Catalysts 

It is useful to divide the development of a manufacturing process into different phases  

Phase 1 Outlining and assessing possible synthetic routes on paper. Here, the decision is made whether to use chemocatalytic steps for making the desired product or to use classical organic synthesis. This decision will depend on a number of considerations, such as the goal of the development, the knowhow of the investigators, the time frame, or the available manpower and equipment 

Phase 2 Demonstrating the chemical feasibility of the key step-which often is the catalytic reaction-and showing that the catalytic step fits into the overall synthetic scheme. 

Phase 3 Optimizing the key catalytic reaction as well as the other steps. Showing the technical feasibility (catalyst separation, metal impurities, etc.) 

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