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Procedure parameter defaults

For brevity, further discussion is restricted to the spatial discretization used to obtain ordinary differential equations. Often the choice and parameters selection for this methods is left to the user of commercial process simulators, while the numerical (time) integrators for ODEs have default settings or sophisticated automatic parameter adjustment routines. For example, using finite difference methods for the time domain, an adaptive selection of the time step is performed that is coupled to the iteration needed to solve the resulting nonlinear algebraic equation system. For additional information concerning numerical procedures and algorithms the reader is referred to the literature. [Pg.249]

The subject population covariate plays a special role in PK similarity assessment, similar to that of formulation in BE assessment. That is, if the influence of formulation on the rest of the parameters Ka, V, CL, etc.) is not adequately represented in the model, then the model will underrepresent the formulation influence on the predictions of PK parameters and may bias the BE assessment results. To further illustrate this, the conventional model building procedure might find the formulation factor insignificant in the model, and if the final model contains no formulation factor, it will predict the AUC and Cmax ratios to be 1 with certainty, that is, producing confidence intervals of length 0. Thus, BE would have to be declared by default. This is clearly unacceptable from the standpoint of traditional BE assessment, which often finds the formulation term insignificant in ANOVA but always produces confidence intervals of positive lengths for the AUC and Cmax ratios. [Pg.423]

A set of default parameters must be estimated at the outset of operation to provide the client with cost of analytical procedures. A sample cost list for radioanalytical chemistry services is illustrated in Table 13.5. The earlier cost data are from a 1990 business plan developed by the authors and the 2004 cost data were extracted from cost proposals by a commercial laboratory. The magnitude of the cost for other analyses can be inferred from their similarity in processing to the cited methods. [Pg.287]

Risk limits have always to be regarded in relation with the procedure used for risk assessment. The degree of conservativeness, of detail etc. in determining risks influence the calculated result (vid. Chaps. 9 and 10). In order to ensure equitable treatment the application of risk limits requires a largely unified, convention-based procedure of analysis. This is achieved, for example in the Netherlands, by using the computer program PH AST [31]. It contains algorithms for the methods of analysis and default values for many of the required input parameters. [Pg.276]

The different lots were taken from an international computer-controlled study to evaluate the process below of our polymerisation procedure and to make sure that every lot will be reproducibly the same. We have achieved this necessary reproducibility, which is following the parameters of lot 604, and we are using a computer-controlled reactor with no default results. [Pg.1063]

The lOBUFFER procedure itself is relatively simple. The parameter list uses default object types such that EN and A are treated as constants and Y is treated as a variable. The use of the range attribute to determine the width of the buffer makes this procedure modular and portable. Note that EXT BUS appears in both instances of the procedure call - once as an in-... [Pg.258]


See other pages where Procedure parameter defaults is mentioned: [Pg.124]    [Pg.256]    [Pg.352]    [Pg.239]    [Pg.195]    [Pg.230]    [Pg.173]    [Pg.1230]    [Pg.343]    [Pg.227]    [Pg.81]    [Pg.55]    [Pg.238]    [Pg.123]    [Pg.658]    [Pg.558]    [Pg.289]    [Pg.325]    [Pg.188]    [Pg.119]    [Pg.218]    [Pg.386]    [Pg.57]    [Pg.193]    [Pg.1389]    [Pg.16]    [Pg.626]    [Pg.1589]    [Pg.457]    [Pg.1282]    [Pg.233]    [Pg.98]    [Pg.242]    [Pg.138]    [Pg.206]    [Pg.207]    [Pg.343]    [Pg.1487]    [Pg.93]    [Pg.607]    [Pg.1035]    [Pg.3345]   
See also in sourсe #XX -- [ Pg.258 ]




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Parameters, default

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