Procarbazine Etoposide

More recently, a German study compared a dose-escalated regimen of BEACOPP (with filgrastim support) with standard-dose bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, prednisone, gemcitabine (BEACOPP) and COPP alternating with ABVD (C—cyclophosphamide instead of mechlorethamine for MOPP).18 The escalated BEACOPP was... [Pg.1378]

ABVD, Adriamycin, bleomycin, vinblastine, and dacarbazine BEACOPP, bleomycin, etoposide, Adriamycin, cyclophosphamide, Oncovin, procarbazine, and prednisone CS, clinical stage. [Pg.718]

CAV = cyclophosphamide/doxorubicin/vincristine CEV = cyclophosphamide/epirubicin/vincristine CCM = cyclophosphamide/lomustine/methotrexate EA = etoposide/doxorubicin VMV/VAC = vincristine, methotrexate, VP-16/vincristine, doxorubicin, cyclophosphamide VAP = vincristine/doxorubicin/ procarbazine PE = cisplatin/etoposide. [Pg.199]

PCV Procarbazine, lomustine, vincristine PEB Cisplatin (platinum), etoposide, bleomycin... [Pg.1160]

Hodgkin s disease (stages III and IV) Combination chemotherapy vinblastine, doxorubicin, dacarbazine, bleomycin Lomustine, etoposide, ifosfamide, interferon, mechlorethamine, vincristine, procarbazine, prednisone... [Pg.1310]

Drugs used in cancer chemotherapy are cytotoxic drugs, hormones, plant derivatives, radioactive isotopes, and miscellaneous agents (e.g., procarbazine, hydroxyurea, mitotane). The plant-based drugs vincristine, vinblastine, vinorel-bine, etoposide, and campothecins. Radioactive isotopes, such as 131 iodine (131 I), are used in the treatment of thyroid tumors. Cytotoxic drugs (e.g., cis-platin, cyclophosphamide, 6-mercaptopurine, 5-fluorouracil, and methotrexate are used for the treatment of cancer. [Pg.287]

Sulfuric acid and potassium permanganate are used to dispose of doxorubicin or daunorubicin wastes. Doxorubicin shows mutagenicity only at high concentrations. Care must be exercised by wearing protective clothing when handling urine and feces after administration of doxorubicin, etoposides, fluorouracil, methotrexate, mitoxantrone, mustine, procarbazine, melphalan, mercaptopurine, vinblastine, vincristine, and hydroxyurea.217... [Pg.361]

Adriamycin (doxorubicin) Cyclophosphamide Oncovin (vincristine) Procarbazine Prednisone Repeat every 21 days BEACOPP (escalated) Bleomycin Etoposide... [Pg.707]

Procarbazine is an alkylating agent that is used in the treatment of Hodgkin s disease in regimens such as MOPP (chlormethine (mechlorethamine), vincristine (Oncovin), procarbazine, and prednisolone) and BEACOPP (bleomycin, etoposide, doxorubicin (Adriamycin), cyclophosphamide, vincristine, procarbazine, and prednisone) (1). It is also used to treat glioblastoma multiforme. [Pg.2929]

Clinically important, potentially hazardous interactions with altretamine, amikacin, aminoglycosides, antineoplastics, bleomycin, busulfan, carboplatin, carmustine, chlorambucil, cisplatin, corticosteroids, cyclophosphamide, cytarabine, dacarbazine, dactinomycin, daunorubicin, docetaxel, doxorubicin, estramustine, etoposide, fludarabine, fluorouracil, gemcitabine, gentamicin, hydroxyurea, idarubicin, ifosfamide, indomethacin, kanamycin, levamisole, lomustine, mechlorethamine, melphalan, mercaptopurine, methotrexate, mitomycin, mitotane, mitoxantrone, neomycin, pentostatin, plicamycin, procarbazine, streptomycin, streptozocin, thioguanine, thiotepa, tobramycin, tretinoin, uracil, vinblastine, vincristine, vinorelbine... [Pg.13]

MINE mesna, ifosfamide, mitoxantrone, and etoposide MOPP mechlorethamine, vincristine (Oncovin), procarbazine, and prednisone... [Pg.2463]

A number of case reports describe an increase in the effects of warfarin, accompanied by bleeding in some cases, caused by an-tineoplastic regimens containing carboplatin, chlormethine, cyclophosphamide, doxorubicin, etoposide, gefitinib, gemcitabine, ifosfamide with mesna, methotrexate, procarbazine, trastuzum-ab, vincristine or vindesine. A decrease in the effects of warfarin has been seen with azathioprine, cyclophosphamide, mercaptop-urine and mitotane, a decrease in the effects of acenocoumarol has been seen with mercaptopurine, and a decrease in the effects of phenprocoumon have l n seen with azathioprine. [Pg.382]

The prothrombin times of an elderly man given warfarin increased by 50 to 100% in the middle of three cycles of treatment with ProMace-Mopp (cyclophosphamide, doxombicin, etoposide, chlormethine, vincristine, procarbazine, methotrexate and prednisone), and he developed a subconjunctival haemorrhage during the first cycle. ... [Pg.382]

Doxorubicin and cyclophosphamide have no clinically relevant effects on the pharmacokinetics of oral or intravenous etoposide. Methotrexate and procarbazine do not affect the pharmacokinetics of oral etoposide. [Pg.631]

A study in 9 patients with a variety of malignant diseases found that treatment with antineoplastics reduced the absorption of a single 160-mg oral dose of verapamil. The verapamil AUC in 8 patients was reduced by 40% (range 7 to 58%), and one patient conversely had a 26% increase. Five patients reeeived a modified COPP regimen (cyclophosphamide, vincristine, procarbazine, prednisone) and four received VAC (vindesine, doxornbicin, cisplatin). It is believed that these antineoplastics damage the lining of the upper part of the small intestine, which impairs the absorption of verapamil. The clinical relevance of this reduction does not appear to have been studied. Note that verapamil may affect levels of anthracyclines , (p.611), etoposide , (p.631), and possibly docetaxel , (p.662). In addition, nifedipine may affect the levels of vincristine , (p.671). [Pg.861]

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