Sucralfate Procainamide

Clinically important, potentially hazardous interactions with aminophylline, amiodarone, antacids, antineoplastics, arsenic, bepridil, bismuth, bismuth subsalicylate, bretylium, calcium salts, cocoa, didanosine, disopyramide, duloxetine, erythromycin, iron, magnesium salts, meptazinol, methylxanthines, NSAIDs, phenothiazines, procainamide, quinidine, rasagiline, sotalol, sucralfate, tizanidine, tricyclic antidepressants, zinc... 

Clinically important, potentially hazardous interactions with amiodarone, amisulpride, amitriptyline, amoxapine, arsenic, bepridil, bretylium, calcium, chlorpromazine, clomipramine, desipramine, disopyramide, doxepin, erythromycin, fluphenazine, imipramine, iron salts, magnesium, mesoridazine, nortriptyline, pentamidine, perphenazine, phenothiazines, pimozide, procainamide, prochlorperazine, promazine, promethazine, protriptyline, quinidine, sotalol, sucralfate, thioridazine, tricyclic antidepressants, trifluoperazine, trimipramine, zinc salts... 

Sucralfate does not appear to affect the absorption of procainamide. 

In 4 healthy subjects sucralfate 1 g taken 30 minutes before a single 250-mg dose of procainamide reduced the mean maximum salivary level of procainamide by 5.3%, but did not significantly affect either the AUC or the rate of absorption. These results suggest that a clinically significant interaction is unlikely. 

Turidstani AAA, Gaber M, Al-Meshal MA, Al-Shora HI, Gouda MW Effect of sucralfate on procainamide absorptioa IntJPharmaceutics 990) 59, R1-R3. 

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