Pro-Banthine - Propantheline bromide

Synonyms N-Methyl-N-(1-methylethyl)-N-[2-[(9H-xanthen-9-y1-carbony1)oxy]ethyl]-2 propanaminium bromide Trade names Pro-Banthine, Propantheline Bromide Sk-Propantheline Bromide... 

Propantheline bromide (Pro-banthine) resembles methantheline chemically (isopropyl groups replace the ethyl substituents on the quaternary N atom). Its pharmacological properties are also similar to those of methantheline, but it is two to five times more potent. It is one of the more widely used of the synthetic muscarinic receptor antagonists. Very high doses block the skeletal neuromuscular junction. The usual clinical dose (15 mg) acts for about 6 h. 

Propantheline bromide (pro-banthine) is a widely used synthetic nonselective muscarinic receptor antagonist. High doses produce the symptoms cf ganglionic blockade toxic doses block the skeletal neuromuscular junction. Its duration of action is comparable to that of atropine. 

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