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Pristimerin

In the NF-kB pathway with celastrol 76, the inhibition of the iKBa degradation is due to the upstream blockage of the kinase activity and not by the direct inhibition of proteasome activity. On the contrary, direct inhibition of proteasome activity was observed with celastrol 76 and pristimerin 2 in prostate cancer cells.90-92 Both triterpene QMs directly inhibited the activity of the 20S subunits of proteasome at 2.5 iM and induced the accumulation of ubiquitinated proteins over time in cells,... [Pg.284]

Dirsch, V. M. Kiemer, A. K. Wagner, H. Vollmar, A. M. The triterpenoid quinonemethide pristimerin inhibits induction of inducible nitric oxide synthase in murine macrophages. Eur. J. Pharm. 1997, 336, 211-217. [Pg.292]

Murayama, T. Eizuru, Y. Yamada, R. Sadanari, H. Matsubara, K Rukung, G. Tolo,F. M. Mungai, G. M. Kofi-Tsekpo, M. Anticytomegalovirus activity of pristimerin, a triterpenoid quinone methide isolated from Maytenus heterophylla (Eckl. Zeyh.). Antiviral Chem. Chemother. 2007, 18, 133-139. [Pg.294]

Thus the HSQC data confirm that, compared to Pristimerin, LGJC3 has one additional CH3 group (a methoxy) and one oxygenated quaternary sp3-hybridized carbon that corresponds to a sp2-hybridized carbon in Pristimerin. [Pg.542]

Many of the aliphatic fragments are now connected to this olefinic/aromatic portion, including the hi3 (CH3) fragment and the quaternary carbon cl9 shared by hi (CH3) and h2 (CH3). The important methyl ether fragment identified from h3 (CH3) is connected, and the correlation from h3 to c32 is particularly interesting since the chemical shift of c32 (196.0 ppm) is typical for a ketone carbonyl group. Comparison with Pristimerin, using... [Pg.548]

The roots of Ethiopian khat contain cathedulins E2, E3, E4, E5, and E6. The root bark itself is orange-red, and this was found to be caused by the presence of triterpenoid quinones (48). Those identified were celastrol (64), pristimerin (65),... [Pg.157]

A very nice example of the oxidation by dioxirane lb where other oxidants failed is the regio- and stereoselective oxidation of C3-C4 enol double bond of quinine methide triterpenes pristimerin 76 and tingenone 77 <1996T10667>. [Pg.657]

The structure of the methylene quinonoid triterpenoid pristimerin (114) has been confirmed by X-ray analysis. The full details of the crystal structure of the triterpenoid dimethyl ester s-lactone from dammar resin have appeared. ... [Pg.174]

See other pages where Pristimerin is mentioned: [Pg.220]    [Pg.269]    [Pg.280]    [Pg.280]    [Pg.281]    [Pg.282]    [Pg.282]    [Pg.284]    [Pg.292]    [Pg.78]    [Pg.538]    [Pg.539]    [Pg.540]    [Pg.540]    [Pg.541]    [Pg.542]    [Pg.542]    [Pg.543]    [Pg.550]    [Pg.269]    [Pg.1184]    [Pg.291]    [Pg.757]   
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Antifeedant activity of pristimerin

Antitumor activity of pristimerin

Aromatic triterpene pristimerin

Of pristimerin

Pristimeria indica pristimerin from

Pristimerin structure

Pristimerin-related compounds

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