Prion knockout mice

A straightforward approach to in vivo hypothesis testing is to generate a knockout mouse for the gene of interest, inoculate with prions and look at the effect on incubation time as compared to wild type controls. Experiments of this nature have been carried out for the anti-inflammatory cytokines interleukin-4 (114), 1110 and 1113 and the chemokine, monocyte chemoattractant protein-1 (Mcpl) [82, 83]. Following intracerebral inoculation with the RML strain of mouse adapted scrapie, no significant differences were seen for mice deficient in either 114,1113 or both. However, for mice... 

Steele AD, Lindquist S, Aguzzi A (2007) The prion protein knockout mouse a phenotype under challenge. Prion 1 83... 

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