Volume, prime

Once process design is complete and each of the process steps characterized, the process is ready for scale-up to pilot or manufacturing scale. A spreadsheet template for scale-up calculations is important and provides a mass balance of buffer volumes, column volumes, priming volumes, product volumes, and waste volumes as well as the tank size and column size. Product volumes can be expressed relative to column volume or can be calculated from a constant concentration, depending on the process step. In addition, starting volumes and titers of conditioned medium as well as step yields and gel or membrane capacity are necessary to cal-... 

Better consistency Air handling Low gas side pressure Low plasma weepage High packing density More efficient Low priming volume... 

Low packing density Poor pulse transmission High priming volume... 

The manufacturer recommends a maximum blood flow of 1500 ml/min, a maximum gas flow of 6 liters/min, and a prime volume of 500-1500 ml. The hole size in the bubbler is 0.007 inch. 

A capillary lung produced by Dow Chemical Co. (38) can pass 1.4 liters/min/m2 of blood. It has siloxane-polycarbonate copolymer hollow fibers of 150 p inside diameter, 25 /x wall thickness, and is 8.5 cm in active length. Prime volume is 100 ml/m2. One square meter transfers 51 ml/min of oxygen and 66 ml/min of carbon dioxide at 1.4 liters/min/m2... 

Figure 2b. Schematic diagram of TIRF flow apparatus. The surge system damps out the pulsations of the peristaltic pump. Helium is used to purge the system of fluorescence-quenching oxygen. The 4-way valve is placed close to the flow-cell to reduce priming volumes to 0.1 ml. The flow-cell/prism assembly is mounted vertically so that fluid enters from the bottom and exists at the top of the chamber. (Reproduced with permission from Ref. 17. Copyright 1983 Academic Press.)...

The extracorporeal, circulation volume or priming volume is small. 

Keywords— haemodialysis, plasmapheresis, circuit pressure, circuit priming volume, circuit flow rate. 

We newly developed the circuit system using the parts of the commercially available circuits. It consists of the series-parallel circuit after we considered the priming volume and the blood fluid viscosity. Fig. 3 shows our proposed schematic circuit diagram including the each portion of priming volume (PV). 

The new circuit system proved to decrease the priming volume by 40%. Apheresis is performed at a blood flows of about 100 ml/min. We secure the blood flow that is necessary... 

Manufacturer Model pt Size Sur ce Area Priming Volume (mL) V02(mL 02/min) Fiber Material MaxQ (L/min) AP at Q , (mmHg)... 

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