Prescribing external factors

It is extremely important to identify delirium in a timely manner. Delirium is a medical emergency because untreated, it often proves fatal. Delirium generally occurs when some external factor interferes with normal brain functioning. The most common causes of delirium are infection (e.g., pneumonia or bladder infections) and the side effect of prescribed medication or drugs of abuse. 

The definition of the customer is thus complex in the pharmaceutical market. One might assume that the physician who prescribes the medicine is the customer. It is true that he or she is still probably the key customer, but the situation is far from clear. Nowadays the prescriber does not operate in a vacuum and is heavily influenced by a number of external factors (Figure 11.5). 

There is no simple relation between the reclassification of a medicine as an OTC and the level of subsequent prescribing [4] external factors may play the dominant role. When aciclovir cream was delisted for the treatment of cold sores the event coincided with heavy advertising for its use. The pubhcity may have affected the extent of OTC use, but there was tittle change in the volume of prescribing. When on the other hand clotrimazole products for the treatment of vaginal candidiasis (thrush) were released for over the counter sale, the increase in overall use was accompanied by a decline in the prescribing of these products. 

In order to correct the deviation of the actual system temperature from the prescribed Tq, Berendsen et al. introduced a proportional method in which the system is weakly coupled to an external heat bath, and at each time step, the velocities of the atoms in the system are multiplied by a scaling factor ... 

Rosenbluth factor of segment /. We generate a set of k — 1 orientations with a distribution prescribed by the bonded interactions (14). These orientations, together with the actual bond between segment — I and /. form the set of k orientations bo. b ). These orientations are used to calculate the external Rosenbluth factor. 

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