Prepn. from amino-acids

Diazo-Salicylic Acid. (N2 )C6H3( 0)X(0).0H mw 164,13 N 17.07% OB to C02 -126.73% yel powder mp, explds at 155°, V sol in hot w and Na carbonate soln v si sol in organic solvents. Prepn is by reacting nitric acid with an ethanolic soln of 5-amino-salicylic hydrochloride. The yield is then hydrolyzed with Na carbonate soln, decolorized with charcoal and recrystd from acetic acid Ref Beil 16, 553... 

Hydroxy-naphthochinon-( 1,2), 7-Hydroxy-1,2-naphthoquinone). (HO).CioHs (0)2, mw 174.16, OB to CO2 —183.74%, dark red microcrysts, mp 203 —204° (decompn). Sol in ale AcOH. Prepn from l-amino-2,7-dioxy-naphthalene by oxidation with chromic-sulfuric acid Refs 1) Beil 8, 299, (634) 2542 2) S. Mededeco O. Bloch, ChemZtr (1935), 2670... 

L-a-aminopropionic acid (5>-2-aminopropanoic acid. C3-H7N02 mol wt 89.09. C 40.44%, H 7.92%, N 15,72%, O 35,92%. CH3CH(NH2)COOH, An amino acid classified as non-essential for the maintenance of growth in rats. Obtained from proteins. Prepn of i>L-form Zelinsky, Stadni-koft Ber. 41, 2061 (1908) Benedict, J. Am. Chem. Soc. 51, 2277 (1929) Cocker. Lapwroth, J. Cham. Soc. 1931, 1399 Kendall, McKenzie, Org. Syn. ColL Vol, I (2nd Ed., 1941) p 21. Laboratory procedure making use of acid hydrolysis of silk fibroin (degummed white silk) Stein et al. J. Biol... 

IT25, Calmagite, 3-Hydroxy-4-[(2-hydroxy-5-methyl-fhasltaio]-l-naphthalenesulfonic acid 1 -(1 -hydroxy-4- Uhyl-2-phenylazo)-2 - n aph thol -4 -sulf onic acid. C,H 4-NftS mol wt 358.38. C 56.97%, H 3.94%, N 7.82%, O B.32%, S 895%. Prepn from I -amino-2-naphthol-4-sul-loik acid and p-cresol Lindstrom, Diehl, Anal. Chem. 32, 1123(1960). 

Etiocobalamin, Cobin-amide dicyanidc vitamin Bl2o Facior B, C H CoN Og mol wt 1042,17. C 57.62%, H 6.96%, Co 5.66%, N 17.47%, O 12 28%. Vitamin factor obtained by removal of the nucleotide from cyanocohal-amin by acid hydrolysis, Isold from calf feces Ford, Porter, Btochem. J- 51, V( 1952) Prepn by acid hydro lysis r Gant et ai,t ibid. 56, XXXIV (1954) Friedrich, Bernhauer, Angew. Chem. 65, 627 (1953). Prepn from factor Vla and D(—)-l amino-2-propanol Bernhauer et al.. Heh. Chim. Acta 43,... 

Kynurenine. a,2-Diamino 7 OXobenzenebutanoic acid 3-a nth rani] oy] alanine. CIDHl2N,0, mol wt 208.21. C 57.68%, H 5.81%, N 13.46%. O 23.05%. An amino acid produced in ihe body frnm tryptophan, lsoln from urine o[ rabbits that had been fed tryptophan Matsuoka, Yoshimat-su, Z. Physio/. Chem. 143, 206 (1925) Butenandl et ai, ibid. 279, 27 (1943) Heidelberger el al, J. Biol, Chem, 179, 143 (1949). Structure and synthesis Butenandt et at., loc. cit. Laboratory prepn hy oxidation of L-iryptophan with a Pseudomonas sp. Hayaishi, Meister, Biochem. Prepn. 3, 108... 

Naphthoic Acid, 2-Naphthatenecarboxylic acid S-naphthoic acid isonaphthoic acid. CnH802 mol wt 172,17. C 76.73%, H 4.68%, O 18.58%. Prepn from 0-acet-ylnaphthalene + NaOCl Newman, Holmes, Org. Syn. coll, vol. II, 428 (1943) from naphthalene + octylsodium Morton et al J. Am. Chem. Soc. 64, 2250 (1942) from 2.amino-naphthaleuesulfonic acid by Sandmeyer reaction Wahl,... 

Norleucine. 2-Aminohexanoic acid a-aminoca-proic acid glycoleucine caprine. C-H (jN02 mol wt 131.17. C 54.94%, H 9.99%, N 10.68%, O 24.39%. CHj(CHj)jCH-(NH2)COOH. An amino acid classified as nonessentia] with respect to its growth effect in rats. Several syntheses prepn from a -bromo -n-caproic acid by action of 25% ammonia at 50-55 Marvel, du Vigneaud, Org. Syn. 4, 3 (1925),... 

Pier antic Acid. 2-Amino-4,(,-dinitrophenoi 4,6-dinitro-2-aminophenol. CjHjNjOj mol wt 199.12. C 36.19%, H 2.539b, N 21.10%, O 40.17%, Prepd from picric acid, coned NH4OH, and HjS followed by acetic acid neutralization of ammonium salt Egerer, J. Biot. Chem. 35, 565 (1918). Prepn of ammonium salt from picric acid, aqueous NH.-soln, and ammonium sulfide Dehn, U,S, pat. 1,472,-791 (1924). 

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