Pregnancy teratogens

Antiepilepsy drugs principles of management withdrawal of therapy pregnancy teratogenic effects epilepsy in children status epilepticus... 

Contraindications Pregnancy (teratogenic), estrogen dependent neoplasm, vaginal bleeding, liver impairment, thromboembolic disorders. 

In mice orally administered a single dose of 70, 150, or 300 mg/kg of the compound jervine on day 8, 9, or 10 of pregnancy, teratogenic effects were observed in some strains of mice (C57BL/6J and A/J) but not in others (Swiss N GP[S] and Swiss Webster). Teratogenic effects included cleft lip, cleft palate, isolated cleft palate, and mandibular and limb malformations. Fetal teratogenicity and maternal and fetal toxicity were highly correlated (Omnell et al. 1990). 

Penicillamine (29) can be effective in patients with refractory RA and may delay progression of erosions, but adverse effects limit its useflilness. The most common adverse side effects for penicillamine are similar to those of parenteral gold therapy, ie, pmritic rash, protein uria, leukopenia, and thrombocytopenia. Decreased or altered taste sensation is a relatively common adverse effect for penicillamine. A monthly blood count, platelet count, and urinalysis are recommended, and also hepatic and renal function should be periodically monitored. Penicillamine is teratogenic and should not be used during pregnancy. 

Albendazole is contraindicated in patients with known hypersensitivity to the drug and during pregnancy (Category C). The drug has exhibited embiyotoxic and teratogenic effects in experimental animals. Albendazole is used cautiously in patients witii hepatic impairment and during lactation. The effects of albendazole are increased with dexamethasone and cimetidina... 

Nausea and vomiting of pregnancy affects the majority of pregnant women the teratogenic potential of the therapy is the primary therapeutic consideration. 

Discuss general methods by which teratogenic risk and drug exposure during pregnancy and lactation can be minimized. 

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