Pregnancy statins

The adverse effects of the statins are mostly limited to slight increases in liver and muscle cnzym cs in the blood. Hypersensitivity reactions are very rare. There is no evidence of tumor-inducing effects. Second-generation effects are suspected, and statins should not be used during pregnancy. 

Ezetimibe rarely can cause allergic reactions. It has been associated with myopathy, more commonly in association with statins but also when used as monotherapy. The mechanism for this adverse effects is unknown. The safety of ezetimibe during pregnancy has not been established. Since all statins are contraindicated in pregnant and nursing women, combination products containing ezetimibe and a statin should not be used by women in childbearing years in the absence of contraception. 

Cholesterol-lowering drugs known as statins modulate the lipid synthesis and are regarded contraindicated during pregnancy [30]. 

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